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July 26, 2026AntioxidantsOpen Access

Comparative Phytochemical Profiling and Phenotypic Senolytic Screening of Botanical Extracts for Oxidative-Stress-Induced Skin-Cell Senescence

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Authors

SPS. ParkJLJi Eun LeeHKHyeon Tae Kang

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Overview

Randomized trial compares antioxidant and senolytic activities in botanical extracts, suggesting distinct mechanisms for skin aging modulation.

Key Points

  • This study aims to investigate the relationship between phytochemical composition, antioxidant capacity, and senolytic activity in botanical extracts.
  • Twenty botanical extracts were screened for total flavonoid content and antioxidant activity.
  • UPLC-Q-TOF-MS phytochemical profiling was employed to analyze extract composition.
  • Phenotypic senolytic screening was conducted using oxidative-stress-induced human foreskin fibroblast models.
  • Chlorella, water lily, green tea, and rosemary showed significant senolytic activity with low cytotoxicity to non-senescent fibroblasts.
  • Green tea extract had the highest antioxidant activity despite differing phytochemical composition from other extracts.
  • Total flavonoid content and antioxidant activity were not correlated with senolytic efficacy.

Cite This Study

Park et al. (2026) studied this question.

synapsesocial.com/papers/6a65a962d3aea3239cd79402https://doi.org/10.3390/antiox15080920
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