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July 26, 2026European Journal Of HaematologyOpen Access

KRAS Mutations Predict Inferior Post‐Remission Outcomes in Newly Diagnosed Acute Myeloid Leukemia With MAPK Pathway Mutations

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Authors

KTKensuke TakaokaSMSarah MottRYRatdanai Yodsuwan

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Overview

Retrospective study assesses KRAS mutations' effect on survival in MAPK-mutated acute myeloid leukemia, suggesting prognostic significance.

Key Points

  • The aim is to evaluate the impact of KRAS and MAPK mutations on survival outcomes in newly diagnosed acute myeloid leukemia.
  • Conducted a retrospective analysis of 74 patients with newly diagnosed MAPK-mutated AML.
  • Endpoints included overall survival, complete remission following treatment, and relapse-free survival.
  • Statistical analyses were performed using logistic and Cox regression models.
  • Estimated 5-year overall survival was 28.9%.
  • KRAS mutation associated with inferior overall survival (HR: 2.14, 95% CI: 1.10–4.17).
  • Median relapse-free survival after achieving complete remission was 13.3 months.

Cite This Study

Takaoka et al. (2026) studied this question.

synapsesocial.com/papers/6a65a962d3aea3239cd79390https://doi.org/10.1111/ejh.70270
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characteristics and clinical outcomes of newly diagnosed acute myeloid leukemia with MAPK pathway mutations: A referral-center retrospective analysis.2026
  2. 2Clinical significance of RAS-MAPK pathway mutations in Acute Myeloid Leukemia: Insights from a retrospective cohort2025
  3. 3Impact of NRAS and/or KRAS mutations on post-transplant outcomes in Acute Myeloid Leukemia: A study on behalf of EBMT-ALWP2025
  4. 4Clearance of RAS pathway mutations prior to allogeneic transplant in Acute Myeloid Leukemia are associated with favorable overall and leukemia free survival2025 · 1 citations
  5. 5Impact of induction response and co-mutations on transplant outcomes in AML with myelodysplasia-related gene mutations: A multicenter retrospective study2025