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July 26, 2026NutrientsOpen Access

Comparative Effects of Live and Heat-Killed Lactobacillus Formulations on DNCB-Induced Dermatitis-like Skin Inflammation in Mice

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Pilot model compares live and heat-killed Lactobacillus effects on inflammation in mice, indicating partial benefits.

This study aims to evaluate the effects of live and heat-killed Lactobacillus formulations on dermatitis-like inflammation in a mouse model.
Conducted an exploratory pilot model development using DNCB to induce dermatitis-like inflammation in male BALB/c mice.
Administered oral interventions of live Lactobacillus, heat-killed Lactobacillus, or a mixed formulation for 21 days post-DNCB exposure.
Assessed outcomes including gross lesion scores, spleen indices, and serum biomarkers.
The mixed formulation showed a lower left-ear erythema score than placebo at Week 2 (significant after Holm correction).
Paraprobiotic and mixed formulations reduced spleen weight compared to control.
Variable histopathological and serum biomarker responses were observed across interventions.

Lin et al. (2026) studied this question.

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