Key result
Extended postoperative enoxaparin associates with ~100% lower PE and DVT rates versus short-term prophylaxis.
Why the study?
Does extended postoperative enoxaparin prophylaxis reduce VTE rates compared to short-term prophylaxis in patients undergoing DIEP flap reconstruction?
Population
358 patients who underwent DIEP flap reconstruction. Excluded: history of prior VTE, coagulopathy, or…
Comparison
Extended postoperative chemoprophylaxis vs Short-term postoperative chemoprophylaxis
Design
Cohort
Authors
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May support extended enoxaparin to lower VTE after DIEP reconstruction; hypothesis-generating and requires randomized confirmation before practice change.
Cohort (n=358)
No
Does extended postoperative enoxaparin prophylaxis reduce VTE rates compared to short-term prophylaxis in patients undergoing DIEP flap reconstruction?
Absolute Event Rate: 0% vs 4.9%
p-value: p=0.04
Extended postoperative enoxaparin prophylaxis significantly reduces PE and DVT rates without increasing bleeding risk in patients undergoing postmastectomy DIEP flap reconstruction.
Parikh et al. (2026) conducted a cohort in Postmastectomy microsurgical breast reconstruction (n=358). Extended postoperative enoxaparin prophylaxis vs. Short-term (2 weeks) enoxaparin prophylaxis was evaluated on Pulmonary embolism (PE) (p=0.04). Extended postoperative enoxaparin prophylaxis significantly reduced the rates of pulmonary embolism (0% vs 4.9%, P=0.04) and DVT compared to short-term prophylaxis following DIEP flap reconstruction.
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