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July 26, 2026MedicineOpen Access

Catheter ablation improves LVEF by ~11% in PVC-induced cardiomyopathy, favoring RVOT and LVOT origins.

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Why the study?

Does catheter ablation improve LVEF in patients with PVC-induced cardiomyopathy, and how do outcomes vary by site of origin?

Population

718 patients with PVC-induced cardiomyopathy (PIC) pooled from 12 studies

Design

Meta-analysis

Key result

Catheter ablation improved LVEF by a mean of 11.0% (95% CI 9.5-12.5; P<.001) in patients with PVC-induced cardiomyopathy, with outcomes favoring RVOT and LVOT origins.

Authors

MAMuhammad AwaisAPAbida PerveenJMJahanzeb Malik

Discussion

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Overview

PVC origin influences ablation success in PIC; extends evidence for site-specific risk stratification and procedural planning.

Key Points

  • This review aims to evaluate the efficacy of catheter ablation for PVC-induced cardiomyopathy and how outcomes vary by PVC origin.
  • Systematic review and meta-analysis of studies from 2000 to 2025
  • Included 12 studies with a total of 718 patients
  • Primary outcomes were change in left ventricular ejection fraction and normalization rates.
  • Ablation improved left ventricular ejection fraction by a mean of 11.0% (95% CI 9.5–12.5; P<0.001)
  • Recovery of normal ejection fraction occurred in approximately 65% of patients
  • Outcomes varied by PVC origin, with RVOT showing ΔLVEF ~12.5% and normalization ~70%.

Study Design

Type

Meta-Analysis (n=718)

Structured PICO

Does catheter ablation improve LVEF in patients with PVC-induced cardiomyopathy, and how do outcomes vary by site of origin?

P
Population
718 patients with PVC-induced cardiomyopathy from 12 studies evaluating catheter ablation stratified by PVC origin.
I
Intervention
Catheter ablation of premature ventricular complexes (PVCs)
O
Outcome
Change in left ventricular ejection fraction (LVEF) and normalization (≥ 50%)surrogate

Main Result

Mean Difference: 11 (95% CI 9.5–12.5)

p-value: p=<.001

Catheter ablation provides substantial and often reversible improvement in LVEF for patients with PVC-induced cardiomyopathy, though success and complication rates are highly dependent on the anatomical site of origin.

Cite This Study

Awais et al. (2026) conducted a meta-analysis in PVC-induced cardiomyopathy (n=718). Catheter ablation was evaluated on Change in LV ejection fraction (LVEF) and normalization (≥ 50%) (Mean 11.0%, 95% CI 9.5-12.5, p=<.001). Catheter ablation improved LVEF by a mean of 11.0% (95% CI 9.5-12.5; P<.001) in patients with PVC-induced cardiomyopathy, with outcomes favoring RVOT and LVOT origins.

synapsesocial.com/papers/6a65a7e0d3aea3239cd7875chttps://doi.org/10.1097/md.0000000000049827
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