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July 26, 2026MetabolitesOpen Access

Comprehensive Profiling of Antioxidant, Antidiabetic, and Cytotoxic Compounds from Morinda lucida Benth Using 1H-NMR- and UHPLC-Q Exactive Orbitrap MS-Based Metabolomics Combined with Molecular Networking and Molecular Docking

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Authors

DTDorcas TlhapiNMNtsoaki Joyce MaleboIMIdah Tichaidza Manduna

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Overview

Randomized trial profiled antioxidant and cytotoxic activities in Morinda lucida, suggesting therapeutic potential.

Key Points

  • This research aims to investigate the phytochemical profiles and pharmacological properties of Morinda lucida.
  • Used 1H-NMR and UHPLC-Q Exactive Orbitrap MS for profiling 77 natural compounds.
  • Conducted in vitro assays for DPPH free radical scavenging, α-glucosidase inhibition, and cytotoxicity.
  • Employed molecular docking to assess interactions between compounds and the α-glucosidase protein.
  • Root extract showed the highest DPPH scavenging activity (IC50 = 7.7550 μg/mL).
  • Stem bark extract exhibited significant α-glucosidase inhibition (IC50 = 79.9 µg/mL).
  • Identified compounds demonstrated notable in silico binding interactions with α-glucosidase.

Cite This Study

Tlhapi et al. (2026) studied this question.

synapsesocial.com/papers/6a65a76fd3aea3239cd783cchttps://doi.org/10.3390/metabo16080523
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