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July 26, 2026Journal of Cardiothoracic SurgeryOpen Access

A 3-gene nomogram model demonstrates excellent diagnostic performance for STEMI with an AUC of ~0.97.

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Population

Transcriptomic data from peripheral blood mononuclear cells of STEMI patients and stable coronary artery…

Comparison

Bioinformatic identification and machine… vs Stable coronary artery disease (CAD) controls

Design

Preclinical

Key result

A nomogram model incorporating brown adipocyte-related genes ASGR2, MCEMP1, and PPARG demonstrated excellent diagnostic performance for STEMI, achieving an AUC of 0.973.

Authors

HLHui LiXCX Z ChenCMChanghui Ma

Discussion

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Overview

BA-related gene signatures may aid STEMI biomarker discovery; leaves open causal roles and clinical translation.

Key Points

  • This study aims to identify and validate key genes associated with brown adipocytes in ST-segment elevation myocardial infarction.
  • Transcriptomic data from STEMI patients and CAD controls were analyzed using limma and WGCNA.
  • Candidate genes identified through intersections of DEGs and module genes were refined using LASSO regression and SVM-RFE.
  • Independent RT-qPCR validation was conducted with a preliminary clinical cohort (n=5 per group).
  • Identified ASGR2, MCEMP1, and PPARG as key genes consistently upregulated in STEMI.
  • Nomogram model incorporating these genes achieved an AUC of 0.973 for diagnostic performance.
  • GSEA revealed enrichment in neutrophil degranulation and Toll-like receptor signaling pathways.

Study Design

Type

Observational (n=10)

Structured PICO

P
Population
Transcriptomic data from STEMI patients and stable CAD controls, with findings validated in an independent clinical cohort of 10 patients (5 per group).
E
Exposure
Bioinformatic identification and machine learning validation of brown adipocyte-related key genes (ASGR2, MCEMP1, PPARG)
C
Comparator
Stable coronary artery disease (CAD) controls
O
Outcome
Identification of key genes and diagnostic performance (AUC) for STEMIsurrogate

Main Result

Effect estimate: AUC 0.973

ASGR2, MCEMP1, and PPARG were identified as brown adipocyte-associated key genes upregulated in STEMI, showing excellent diagnostic potential and immune-metabolic relevance.

Cite This Study

Li et al. (2026) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=10). ST-segment elevation myocardial infarction (STEMI) vs. Stable coronary artery disease (CAD) was evaluated on Diagnostic performance of a 3-gene nomogram model (AUC 0.973). A nomogram model incorporating brown adipocyte-related genes ASGR2, MCEMP1, and PPARG demonstrated excellent diagnostic performance for STEMI, achieving an AUC of 0.973.

synapsesocial.com/papers/6a65a3a3d3aea3239cd76a66https://doi.org/10.1186/s13019-026-04649-x
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