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July 24, 2026Egyptian Journal of BronchologyOpen Access

TTE PASP correlates with invasive PAC but shows limited agreement.

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Why the study?

Does transthoracic echocardiography accurately correlate and agree with invasive pulmonary artery catheterization for hemodynamic assessment in patients with pulmonary arterial hypertension?

Population

29 patients with pulmonary arterial hypertension (PAH), mean age 44 ± 15 years, 16% male.

Comparison

Transthoracic echocardiography for hemodynamic… vs Invasive pulmonary artery catheterization (PAC)

Design

Cross-sectional

Key result

Transthoracic echocardiography PASP measurements correlated significantly with invasive pulmonary artery catheterization (r=0.693, p<0.001), though agreement between the methods remained limited.

Authors

MAMostafa K. AhmedATAly TohamyMAMostafa H. Ali

Discussion

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Overview

Echocardiographic PASP may aid noninvasive screening in PAH; leaves open replacement of catheterization given limited agreement.

Key Points

  • This study aims to analyze the correlation and agreement between echocardiography and invasive hemodynamic assessments in patients with pulmonary arterial hypertension.
  • Cross-sectional observational study involving patients with pulmonary arterial hypertension.
  • Patients underwent both transthoracic echocardiography and pulmonary artery catheterization within a short time interval.
  • Correlations between echocardiographic and invasive hemodynamics were evaluated using Bland–Altman analysis.
  • Echocardiographic pulmonary artery systolic pressure (PASP) and mean pulmonary artery pressure (PAMP) showed significant correlations with invasive measurements (r = 0.693, p < 0.001; r = 0.632, p < 0.001).
  • Bland–Altman analysis indicated small biases but wide limits of agreement in PASP measurements.
  • Right ventricle functional indices correlated significantly with invasive hemodynamics, particularly TAPSE/PASP and RVFAC/PASP demonstrating relationships with exercise capacity and SvO2.

Study Design

Type

Cross-Sectional (n=29)

Structured PICO

Does transthoracic echocardiography accurately correlate and agree with invasive pulmonary artery catheterization for hemodynamic assessment in patients with pulmonary arterial hypertension?

P
Population
29 patients (mean age 44 years, 84% female) with pulmonary arterial hypertension who underwent transthoracic echocardiography and pulmonary artery catheterization within a short time interval.
E
Exposure
Transthoracic echocardiography (TTE) for hemodynamic assessment
C
Comparator
Invasive pulmonary artery catheterization (PAC)
O
Outcome
Correlation and agreement between TTE and PAC derived hemodynamics (PASP, PAMP, PADP)surrogate

Main Result

Effect estimate: r = 0.693

Absolute Event Rate: 78.21% vs 78.31%

p-value: p=<0.001

Echocardiography provides a reasonable noninvasive approximation of pulmonary hemodynamics in PAH, but its wide limits of agreement with invasive measurements suggest it should complement rather than replace right heart catheterization.

Limitations

  • Agreement with invasive measurements remains limited
  • Wide limits of agreement in Bland-Altman analysis

Cite This Study

Ahmed et al. (2026) conducted a cross-sectional in pulmonary arterial hypertension (PAH) (n=29). Transthoracic echocardiography (TTE) vs. Pulmonary artery catheterization (PAC) was evaluated on Correlation and agreement between TTE and PAC derived hemodynamics (PASP) (r = 0.693, p=<0.001). Transthoracic echocardiography PASP measurements correlated significantly with invasive pulmonary artery catheterization (r=0.693, p<0.001), though agreement between the methods remained limited.

synapsesocial.com/papers/6a630179395161722cd16077https://doi.org/10.1186/s43168-026-00624-1
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