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July 24, 2026PharmaceuticsOpen Access

Curcumin-Loaded Microemulsion Gel: An Optimized and Rheologically Acceptable Formulation with Conducive Dermatokinetics for Topical Breast Cancer Therapy

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Authors

MBMd. Abul BarkatSRShakilur RahmanHBHarshita Barkat

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Overview

Randomized trial demonstrates improved drug delivery and anticancer efficacy of curcumin gel in breast cancer, suggesting a new treatment approach.

Key Points

  • The aim is to develop an optimized curcumin-loaded microemulsion gel for effective topical breast cancer therapy.
  • Developed a curcumin-loaded microemulsion using Box–Behnken design.
  • Incorporated microemulsion into Carbopol 934 gel for topical application.
  • Conducted in vitro tests for cytotoxicity, drug release, and skin penetration analysis.
  • CUR-ME showed superior cytotoxicity against MCF-7 cells with IC50 of 8.89 µg/mL vs 9.83 µg/mL for free curcumin.
  • Enhanced apoptosis and reactive oxygen species generation in CUR-ME-treated cells confirmed improved anticancer activity.
  • In vitro drug release and rheological studies indicated suitable formulation characteristics for topical use.

Cite This Study

Barkat et al. (2026) studied this question.

synapsesocial.com/papers/6a6300f2395161722cd15c0fhttps://doi.org/10.3390/pharmaceutics18070897
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