What is the clinical evidence from this study?

Study design: Observational. Population: Chronic kidney disease and hypertension (n=100). Intervention: Antihypertensive therapy. Primary outcome: Changes in systolic blood pressure, diastolic blood pressure, and serum creatinine (p=<0.001).

What question did this study set out to answer?

This study aims to evaluate antihypertensive prescribing patterns and subsequent blood pressure outcomes in patients with chronic kidney disease (CKD).

July 23, 2026The Egyptian Journal of Internal MedicineOpen Access

Antihypertensive therapy associates with a ~26 mmHg SBP drop, lower DBP, and reduced serum creatinine.

Q: What are the key findings of this study?

Antihypertensive therapy was associated with significant reductions in systolic blood pressure (160.13 to 134.20 mmHg), diastolic blood pressure, and serum creatinine over 6 months (all p<0.001).

Q: What question did this study set out to answer?

This study aims to evaluate antihypertensive prescribing patterns and subsequent blood pressure outcomes in patients with chronic kidney disease (CKD).

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Why the study?

Does antihypertensive therapy improve blood pressure and serum creatinine in adults with chronic kidney disease and hypertension?

Population

100 adults with chronic kidney disease and hypertension attending a tertiary-care teaching hospital. 64%…

Design

Cohort

Follow-up

6 months

Key result

Antihypertensive therapy was associated with significant reductions in systolic blood pressure (160.13 to 134.20 mmHg), diastolic blood pressure, and serum creatinine over 6 months (all p<0.001).

Authors

SRShamama Rehman MBMd Abdul Bari MFMaryam Fatima

Discussion

Member takes

Overview

Prescribing patterns in advanced CKD merit review in practice; leaves open optimal regimens and outcomes pending controlled trials.

Key Points

This study aims to evaluate antihypertensive prescribing patterns and subsequent blood pressure outcomes in patients with chronic kidney disease (CKD).
Conducted a six-month prospective observational study among 100 adults with CKD and hypertension
Recorded demographic data, CKD stage, antihypertensive prescriptions, and clinical parameters at baseline and follow-up
Analyzed changes using paired Student's t-test.
Systolic blood pressure decreased from 160.13±25.26 mmHg to 134.20±19.77 mmHg (p<0.001)
Diastolic blood pressure dropped from 92.63±13.07 mmHg to 80.10±10.94 mmHg (p<0.001)
Serum creatinine improved from 5.59±3.73 mg/dL to 4.04±3.20 mg/dL (p<0.001).

Study Design

Type

Observational (n=100)

Multicenter

Structured PICO

Does antihypertensive therapy improve blood pressure and serum creatinine in adults with chronic kidney disease and hypertension?

Population

100 adults with chronic kidney disease and hypertension attending a tertiary-care teaching hospital, followed for six months.

Exposure

Antihypertensive therapy (predominantly diuretics [37.8%] and calcium channel blockers [29.0%]) over 6 months

Outcome

Changes in systolic blood pressure, diastolic blood pressure, and serum creatinine at 6 months follow-upsurrogate

Main Result

p-value: p=<0.001

In a real-world cohort of patients with advanced CKD and hypertension, treatment predominantly with diuretics and calcium channel blockers was associated with significant improvements in blood pressure and serum creatinine over 6 months.

Limitations

Observational design cannot prove treatment efficacy
Single center study
Short follow-up duration
Observational findings should not be interpreted as evidence of treatment efficacy
Single-center study

Cite This Study

Rehman et al. (2026) conducted an observational in Chronic kidney disease and hypertension (n=100). Antihypertensive therapy was evaluated on Changes in systolic blood pressure, diastolic blood pressure, and serum creatinine (p=<0.001). Antihypertensive therapy was associated with significant reductions in systolic blood pressure (160.13 to 134.20 mmHg), diastolic blood pressure, and serum creatinine over 6 months (all p<0.001).

synapsesocial.com/papers/6a61b02ffaa9903c5116ac53 https://doi.org/10.1186/s43162-026-00681-4

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July 23, 2026The Egyptian Journal of Internal MedicineOpen Access

Antihypertensive therapy associates with a ~26 mmHg SBP drop, lower DBP, and reduced serum creatinine.

View Full Paper

Ask AI

Bookmark

Why the study?

Does antihypertensive therapy improve blood pressure and serum creatinine in adults with chronic kidney disease and hypertension?

Population

100 adults with chronic kidney disease and hypertension attending a tertiary-care teaching hospital. 64%…

Design

Cohort

Follow-up

6 months

Key result

Antihypertensive therapy was associated with significant reductions in systolic blood pressure (160.13 to 134.20 mmHg), diastolic blood pressure, and serum creatinine over 6 months (all p<0.001).

Authors

SRShamama Rehman MBMd Abdul Bari MFMaryam Fatima

Discussion

Member takes

Overview

Prescribing patterns in advanced CKD merit review in practice; leaves open optimal regimens and outcomes pending controlled trials.

Key Points

This study aims to evaluate antihypertensive prescribing patterns and subsequent blood pressure outcomes in patients with chronic kidney disease (CKD).
Conducted a six-month prospective observational study among 100 adults with CKD and hypertension
Recorded demographic data, CKD stage, antihypertensive prescriptions, and clinical parameters at baseline and follow-up
Analyzed changes using paired Student's t-test.
Systolic blood pressure decreased from 160.13±25.26 mmHg to 134.20±19.77 mmHg (p<0.001)
Diastolic blood pressure dropped from 92.63±13.07 mmHg to 80.10±10.94 mmHg (p<0.001)
Serum creatinine improved from 5.59±3.73 mg/dL to 4.04±3.20 mg/dL (p<0.001).

Study Design

Type

Observational (n=100)

Multicenter

Structured PICO

Does antihypertensive therapy improve blood pressure and serum creatinine in adults with chronic kidney disease and hypertension?

Population

100 adults with chronic kidney disease and hypertension attending a tertiary-care teaching hospital, followed for six months.

Exposure

Antihypertensive therapy (predominantly diuretics [37.8%] and calcium channel blockers [29.0%]) over 6 months

Outcome

Changes in systolic blood pressure, diastolic blood pressure, and serum creatinine at 6 months follow-upsurrogate

Main Result

p-value: p=<0.001

Limitations

Observational design cannot prove treatment efficacy
Single center study
Short follow-up duration
Observational findings should not be interpreted as evidence of treatment efficacy
Single-center study

Cite This Study

synapsesocial.com/papers/6a61b02ffaa9903c5116ac53 https://doi.org/10.1186/s43162-026-00681-4

Also Consider

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