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July 23, 2026Biomechanics and Modeling in MechanobiologyOpen Access

Carotid FMD models exhibit increased velocities and shear stresses versus healthy geometries, indicating adverse hemodynamics.

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Population

Patient-specific vascular geometries representing healthy, focal, non-focal, and severe non-focal carotid…

Comparison

Two-way coupled three-dimensional… vs Healthy carotid geometry

Design

Preclinical

Key result

Carotid fibromuscular dysplasia models exhibited increased velocities, wall shear stresses, and oscillatory shear indices compared to healthy geometries, indicating adverse haemodynamics.

Authors

KMKaveh MoghadasiGMGhayesh MHEHEric Hu

Discussion

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Overview

May identify biomechanical biomarkers in carotid FMD; leaves open their clinical utility pending validation.

Key Points

  • The study examines the biomechanical behavior of the carotid artery in patients with fibromuscular dysplasia (FMD).
  • Developed a two-way coupled three-dimensional fluid-structure interaction (FSI) model.
  • Integrated patient-specific vascular geometries and non-Newtonian turbulent blood flow.
  • Analyzed haemodynamic biomarkers and biomechanical responses across different carotid FMD types.
  • FMD cases showed increased velocities and wall shear stresses with decreased pressure gradients at the distal end.
  • Elevated oscillatory shear index (OSI) and relative residence time (RRT) noted in all FMD models.
  • Non-focal phenotypes exhibited the largest radial deformation, while focal configurations experienced the highest von-Mises stresses.

Structured PICO

P
Population
Patient-specific vascular geometries representing healthy, focal, non-focal, and severe non-focal carotid fibromuscular dysplasia (FMD)
E
Exposure
Two-way coupled three-dimensional (3D) fluid-structure interaction (FSI) modeling
C
Comparator
Healthy carotid geometry
O
Outcome
Haemodynamic biomarkers and biomechanical wall responses (velocities, wall shear stresses, pressure gradients, OSI, RRT, radial deformation, von-Mises stresses)surrogate

Computational fluid-structure interaction modeling demonstrates that increasing morphological complexity in carotid FMD leads to progressively adverse haemodynamics and mechanical forces.

Cite This Study

Moghadasi et al. (2026) studied Carotid fibromuscular dysplasia. Carotid fibromuscular dysplasia (FMD) phenotypes vs. Healthy carotid geometry was evaluated on Haemodynamic biomarkers and biomechanical wall responses. Carotid fibromuscular dysplasia models exhibited increased velocities, wall shear stresses, and oscillatory shear indices compared to healthy geometries, indicating adverse haemodynamics.

synapsesocial.com/papers/6a61b004faa9903c5116aac9https://doi.org/10.1007/s10237-026-02099-x
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