Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 22, 2026Bulletin of the National Research Centre/Bulletin of the National Research CenterOpen Access

Conservative management yields complete recovery from extreme hyperbilirubinemia following minimally invasive MVR.

View Full Paper
Ask AI
Bookmark
Share

Population

30-year-old woman with progressive exertional dyspnea secondary to severe congenital parachute mitral valve…

Design

Case_report

Key result

Conservative management resulted in complete clinical and biochemical recovery from extreme direct hyperbilirubinemia (peak total bilirubin 40.6 mg/dL) following minimally invasive mitral valve replacement.

Authors

ZAZakiur Rehman Abdul Rehman AnsariZHZainul Abedein HamdulayAKAzizullah Khan

Discussion

Loading...

Member takes

Overview

Alerts clinicians to monitor post-MVR bilirubin; case reports leave open generalizability and mechanisms.

Key Points

  • To highlight a rare case of extreme reversible hyperbilirubinemia following hypoxic-ischemic hepatitis after mitral valve surgery.
  • Case report of a 30-year-old woman undergoing minimally invasive mitral valve replacement.
  • Detailed perioperative assessment, including ultrasonography, CT, MRCP, and serological tests to rule out other causes of liver dysfunction.
  • Conservative management with supportive care and ursodeoxycholic acid.
  • Direct bilirubin peaked at 35.8 mg/dL with complete recovery.
  • Acute liver injury characterized by elevated AST (920 U/L) and ALT (2256 U/L) levels.
  • Progressive biochemical improvement following conservative management.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

P
Population
A 30-year-old woman with severe congenital parachute mitral valve who developed extreme reversible direct hyperbilirubinemia following minimally invasive mitral valve replacement.
I
Intervention
Minimally invasive mitral valve replacement through a right mini-thoracotomy using peripheral femoro-femoral cardiopulmonary bypass
O
Outcome
Postoperative liver injury and recovery

Extreme direct hyperbilirubinemia following hypoxic-ischemic hepatitis after complex cardiac surgery can be completely reversible with conservative management.

Limitations

  • Describes a single patient and cannot establish causality
  • Liver biopsy was not performed for histopathological confirmation
  • Some intraoperative perfusion parameters were obtained retrospectively from operative records, limiting detailed assessment of perfusion dynamics

Cite This Study

Ansari et al. (2026) conducted a case report in Congenital parachute mitral valve with severe mitral stenosis (n=1). Minimally invasive mitral valve replacement was evaluated on Resolution of hyperbilirubinemia. Conservative management resulted in complete clinical and biochemical recovery from extreme direct hyperbilirubinemia (peak total bilirubin 40.6 mg/dL) following minimally invasive mitral valve replacement.

synapsesocial.com/papers/6a605ea14163e025518d852bhttps://doi.org/10.1186/s42269-026-01469-w
View Full Paper
Ask AI
Bookmark
Share