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July 18, 2026Orthopaedic Proceedings

Lower admission serum albumin linked to ~41% higher mortality in peri-prosthetic femoral fractures.

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Why the study?

Are admission serum albumin and AMT-10 scores independent predictors of mortality in patients with peri-prosthetic femoral fractures?

Population

67 patients admitted to a single centre district general hospital sustaining peri-prosthetic femoral fractures

Design

Cohort

Follow-up

up to 2 years

Key result

Lower admission serum albumin levels were independent predictors of 1-year and 2-year mortality in patients with peri-prosthetic femoral fractures (Adjusted OR 0.71; 95% CI 0.55-0.92; P=0.0083).

Authors

ACA ColeLEL. EliasAEA. Evans

Discussion

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Overview

Lower albumin identifies higher 1-2 year mortality risk after peri-prosthetic femoral fracture; hypothesis-generating for nutritional interventions pending prospective trials.

Key Points

  • The study aims to explore the association between serum investigations, patient characteristics, and mortality rates in patients sustaining peri-prosthetic femoral fractures.
  • Retrospective review of 67 patients admitted for peri-prosthetic femoral fractures at a single-center hospital.
  • Recorded data included age, gender, ASA grade, cognitive function (AMT-10), baseline mobility, and admission serum investigations.
  • Analyzed mortality rates at 30 days, 1 year, and 2 years post-admission.
  • Mortality rates were 4.4% at 30 days, 10.3% at 1 year, and 16.2% at 2 years.
  • Lower albumin levels were an independent predictor of mortality at 1 year (Adjusted OR 0.71, 95% CI 0.55–0.92, P=0.0083).
  • Lower AMT-10 scores also predicted mortality at 1 year (Adjusted OR 0.67, 95% CI 0.49–0.90, P=0.0075).

Study Design

Type

Cohort (n=67)

Multicenter

No

Structured PICO

Are admission serum albumin and AMT-10 scores independent predictors of mortality in patients with peri-prosthetic femoral fractures?

P
Population
67 consecutive patients admitted to a single center with peri-prosthetic femoral fractures, followed for up to 2 years.
E
Exposure
Admission serum albumin and AMT-10 assessment (prognostic markers)
O
Outcome
1-year and 2-year mortalityhard clinical

Main Result

Odds Ratio: 0.71 (95% CI 0.55–0.92)

p-value: p=0.0083

Admission serum albumin and AMT-10 scores can be utilized as independent predictors of 1- and 2-year mortality in patients sustaining peri-prosthetic femoral fractures.

Cite This Study

Cole et al. (2026) conducted a cohort in Peri-prosthetic femoral fractures (PPFF) (n=67). Admission serum albumin was evaluated on 1-year and 2-year mortality (Adjusted OR 0.71, 95% CI 0.55-0.92, p=0.0083). Lower admission serum albumin levels were independent predictors of 1-year and 2-year mortality in patients with peri-prosthetic femoral fractures (Adjusted OR 0.71; 95% CI 0.55-0.92; P=0.0083).

synapsesocial.com/papers/6a5b39288167787360d24f64https://doi.org/10.1302/1358-992x.2026.5.020
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