Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 18, 2026Pakistan Armed Forces Medical JournalOpen Access

Iron deficiency anemia in HFrEF is linked to ~22 m shorter 6MWT and lower KCCQ scores.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does iron deficiency anemia impair functional status and quality of life in adult patients with chronic HFrEF?

Population

320 adult patients with chronic heart failure with reduced ejection fraction (HFrEF)

Comparison

Iron deficiency anemia vs No iron deficiency anemia

Design

Cross-sectional

Key result

Iron deficiency anemia in patients with HFrEF was associated with significantly lower 6-minute walk test distance (280.98 vs. 303.32 m, p<0.001) and KCCQ scores (42.72 vs. 47.28, p<0.001).

Authors

AHAhtasham Ul HassanFSFarrukh SherASAasim Ali Sajid

Discussion

Loading...

Member takes

Overview

Should not yet change HFrEF management; cross-sectional data leaves open causal effects of iron repletion on outcomes.

Key Points

  • Evaluate the effects of iron deficiency anemia on the functional status of patients with heart failure with reduced ejection fraction.
  • Analytical cross-sectional study with 320 patients with chronic HFrEF.
  • Functional status assessed using NYHA class, 6MWT, and KCCQ.
  • Multivariable linear regression identified predictors of 6MWT distance.
  • 61.3% of patients had iron deficiency anemia (IDA).
  • Patients with IDA had significantly lower mean haemoglobin (11.17 g/dL vs 13.54 g/dL, p<0.001) and 6MWT distance (280.98 m vs 303.32 m, p<0.001).
  • Regression analysis indicated transferrin saturation (β=0.18, p=0.015) and haemoglobin (β=0.23, p=0.011) as independent predictors of 6MWT distance.

Study Design

Type

Cross-Sectional (n=320)

Multicenter

No

Structured PICO

Does iron deficiency anemia impair functional status and quality of life in adult patients with chronic HFrEF?

P
Population
320 adult patients with chronic heart failure with reduced ejection fraction.
E
Exposure
Iron deficiency anemia (defined as serum ferritin <100 µg/L or 100–299 µg/L with transferrin saturation [TSAT] <20%)
C
Comparator
No iron deficiency anemia
O
Outcome
Functional status assessed by New York Heart Association (NYHA) class, six-minute walk test (6MWT) distance, and Kansas City Cardiomyopathy Questionnaire (KCCQ) scorepatient reported

Main Result

Absolute Event Rate: 280.98% vs 303.32%

p-value: p=<0.001

Iron deficiency anemia is highly prevalent in HFrEF patients and is associated with significantly impaired functional capacity and quality of life.

Cite This Study

Hassan et al. (2026) conducted a cross-sectional in Heart failure with reduced ejection fraction (HFrEF) (n=320). Iron deficiency anemia vs. Non-iron deficiency anemia was evaluated on 6-minute walk test (6MWT) distance (p=<0.001). Iron deficiency anemia in patients with HFrEF was associated with significantly lower 6-minute walk test distance (280.98 vs. 303.32 m, p<0.001) and KCCQ scores (42.72 vs. 47.28, p<0.001).

synapsesocial.com/papers/6a5b38f68167787360d24de0https://doi.org/10.51253/pafmj.v76isuppl-7.13980
View Full Paper
Ask AI
Bookmark
Share