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July 18, 2026Journal of Drug Delivery and TherapeuticsOpen Access

Acute 2g coffee intake transiently elevates BP in both hypertensive and normotensive adults.

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Why the study?

Does acute coffee consumption increase blood pressure, pulse rate, and oxygen saturation in hypertensive and normotensive patients?

Population

500 adult volunteers at a tertiary health institution in South-East Nigeria. Hypertensive group: mean age…

Comparison

2 grams of coffee granules dissolved in 200ml of… vs Baseline values (pre-consumption)

Design

Cohort

Follow-up

5 hours

Key result

Acute consumption of 2g of coffee caused a transient, significant elevation of systolic and diastolic blood pressure (P≤0.001) in both hypertensive and normotensive adults.

Authors

CACCA Azikiwe AzikiweCCChukwuma ChijiokeBOBU Ogbonna

Discussion

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Overview

May affect acute BP parameters in hypertensives; leaves open whether findings warrant practice changes pending confirmatory trials.

Key Points

  • This study aims to determine the acute effects of coffee on cardiovascular parameters in hypertensive and normotensive patients.
  • 500 adult volunteers (250 hypertensive and 250 normotensive) participated.
  • 2 grams of coffee granules were mixed with 200ml of hot water and consumed.
  • Blood pressure, pulse rate, and SpO2 were measured before and at intervals after coffee consumption.
  • Systolic and diastolic blood pressure significantly elevated at 30 minutes to 2 hours post-consumption (P≤0.001).
  • Pulse rates rose at 15 minutes post-coffee and returned to baseline by 3 hours.
  • SpO2 remained unchanged throughout the study.

Structured PICO

Does acute coffee consumption increase blood pressure, pulse rate, and oxygen saturation in hypertensive and normotensive patients?

P
Population
500 adult volunteers, comprising 250 hypertensive and 250 normotensive individuals, monitored for 5 hours after acute coffee consumption.
I
Intervention
2 grams of coffee granules dissolved in 200ml of hot water, administered as a single dose
C
Comparator
Baseline values (pre-consumption)
O
Outcome
Changes in systolic blood pressure, diastolic blood pressure, pulse rate, and finger oxygen saturation (SpO2) measured at 15 minutes post-consumption and every 30 minutes for 5 hourssurrogate

Main Result

p-value: p=≤0.001

Acute coffee consumption causes a transient but significant elevation in blood pressure and pulse rate in both hypertensive and normotensive individuals, suggesting a need for moderation in hypertensive patients.

Cite This Study

Azikiwe et al. (2026) studied Hypertension (n=500). Coffee vs. Baseline values was evaluated on Elevation of systolic and diastolic blood pressure from 30 minutes to 2 hours post consumption (p=≤0.001). Acute consumption of 2g of coffee caused a transient, significant elevation of systolic and diastolic blood pressure (P≤0.001) in both hypertensive and normotensive adults.

synapsesocial.com/papers/6a5b181c18557b26c203a198https://doi.org/10.22270/jddt.v16i7.7881
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Also Consider

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  1. 1[Coffee and hypertension: current insights and perspectives].2025
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  3. 3Correlations Between Coffee Intake, Glycemic Control, Cardiovascular Risk, and Sleep in Type 2 Diabetes and Hypertension: A 12-Month Observational Study2025 · 6 citations
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  5. 5A cross-sectional analysis of coffee intake and hypertension prevalence: results from the NHANES 2005–20202025 · 2 citations