Prospective study evaluates inflammatory activity's impact on anorectal function in ulcerative colitis, implying persistent symptoms even after treatment.
Key Points
This study aims to understand how inflammatory activity affects anorectal function and symptom development in patients with ulcerative colitis.
Conducted a prospective observational study on patients with ulcerative colitis and active disease.
Performed clinical, biochemical, and endoscopic assessments along with high-resolution anorectal manometry and rectal electronic barostat testing.
Evaluated two time points: during active disease and 4-6 months after treatment initiation.
66.7% of patients reported fecal incontinence during active disease; after treatment, 32.3% remained symptomatic.
Greater endoscopic and histological activity correlated with reduced rectal compliance and increased sensitivity (all p < 0.05).
Barostat parameters remained altered post-treatment compared to healthy controls, indicating ongoing dysfunction.