What is the clinical evidence from this study?

Study design: Cohort. Population: Acute chest pain (n=348). Intervention: SVEAT score vs. HEART and TIMI scores. Primary outcome: 90-day major adverse cardiac events (MACE) (AUC 0.806).

What question did this study set out to answer?

This study aimed to evaluate the diagnostic performance of the SVEAT score in predicting 90-day major adverse cardiac events (MACE) in patients with acute chest pain.

July 18, 2026BMC Emergency MedicineOpen Access

SVEAT predicts 90-day MACE with ~0.81 AUC, trading lower sensitivity for higher specificity versus HEART and TIMI.

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Why the study?

Does the SVEAT score improve prediction of 90-day MACE compared to HEART and TIMI scores in emergency department patients presenting with acute chest pain?

Population

348 patients presenting to the emergency department with acute chest pain

Comparison

SVEAT score vs HEART score and TIMI score

Design

Cohort

Follow-up

90 days

Key result

The SVEAT score predicted 90-day MACE with an AUC of 0.806, demonstrating higher specificity (0.86) but lower sensitivity (0.56) compared to the HEART and TIMI scores.

Authors

AAAli Ayvaz AAAkkan Avcı MTMustafa Oğuz Tuğcan

Discussion

Member takes

Overview

SVEAT may aid chest pain triage via higher specificity; hypothesis-generating and should not yet change practice pending validation.

Key Points

This study aimed to evaluate the diagnostic performance of the SVEAT score in predicting 90-day major adverse cardiac events (MACE) in patients with acute chest pain.
Included 348 patients presenting with acute chest pain
Measured high-sensitivity troponin I at admission and 2 hours later
Calculated SVEAT, HEART, and TIMI scores, with follow-up for MACE over 90 days.
MACE occurred in 7.2% of patients during the 90-day follow-up
SVEAT score had the highest AUC of 0.806 compared to HEART (0.756) and TIMI (0.753) scores
At a cut-off of 4, the SVEAT score had a sensitivity of 0.56 and specificity of 0.86.

Study Design

Type

Cohort (n=348)

Structured PICO

Does the SVEAT score improve prediction of 90-day MACE compared to HEART and TIMI scores in emergency department patients presenting with acute chest pain?

Population

348 patients presenting to the emergency department with acute chest pain, followed for 90 days for the occurrence of major adverse cardiac events.

Exposure

SVEAT (Symptoms, Vascular Disease History, Electrocardiography, Age, and Troponin) score

Comparator

HEART score and TIMI score

Outcome

90-day major adverse cardiac events (MACE)composite

Main Result

Effect estimate: AUC 0.806

The SVEAT score shows higher specificity but lower sensitivity than HEART and TIMI scores for predicting 90-day MACE in ED patients with chest pain, suggesting potential utility as a rule-in rather than a standalone screening tool.

Limitations

Relatively low sensitivity limits its utility as a standalone screening tool.
relatively low sensitivity, which limits its utility as a standalone screening tool

Cite This Study

Ayvaz et al. (2026) conducted a cohort in Acute chest pain (n=348). SVEAT score vs. HEART and TIMI scores was evaluated on 90-day major adverse cardiac events (MACE) (AUC 0.806). The SVEAT score predicted 90-day MACE with an AUC of 0.806, demonstrating higher specificity (0.86) but lower sensitivity (0.56) compared to the HEART and TIMI scores.

synapsesocial.com/papers/6a5b178d18557b26c2039b2d https://doi.org/10.1186/s12873-026-01685-7

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July 18, 2026BMC Emergency MedicineOpen Access

SVEAT predicts 90-day MACE with ~0.81 AUC, trading lower sensitivity for higher specificity versus HEART and TIMI.

View Full Paper

Ask AI

Bookmark

Why the study?

Does the SVEAT score improve prediction of 90-day MACE compared to HEART and TIMI scores in emergency department patients presenting with acute chest pain?

Population

348 patients presenting to the emergency department with acute chest pain

Comparison

SVEAT score vs HEART score and TIMI score

Design

Cohort

Follow-up

90 days

Key result

The SVEAT score predicted 90-day MACE with an AUC of 0.806, demonstrating higher specificity (0.86) but lower sensitivity (0.56) compared to the HEART and TIMI scores.

Authors

AAAli Ayvaz AAAkkan Avcı MTMustafa Oğuz Tuğcan

Discussion

Member takes

Overview

SVEAT may aid chest pain triage via higher specificity; hypothesis-generating and should not yet change practice pending validation.

Key Points

This study aimed to evaluate the diagnostic performance of the SVEAT score in predicting 90-day major adverse cardiac events (MACE) in patients with acute chest pain.
Included 348 patients presenting with acute chest pain
Measured high-sensitivity troponin I at admission and 2 hours later
Calculated SVEAT, HEART, and TIMI scores, with follow-up for MACE over 90 days.
MACE occurred in 7.2% of patients during the 90-day follow-up
SVEAT score had the highest AUC of 0.806 compared to HEART (0.756) and TIMI (0.753) scores
At a cut-off of 4, the SVEAT score had a sensitivity of 0.56 and specificity of 0.86.

Study Design

Type

Cohort (n=348)

Structured PICO

Does the SVEAT score improve prediction of 90-day MACE compared to HEART and TIMI scores in emergency department patients presenting with acute chest pain?

Population

348 patients presenting to the emergency department with acute chest pain, followed for 90 days for the occurrence of major adverse cardiac events.

Exposure

SVEAT (Symptoms, Vascular Disease History, Electrocardiography, Age, and Troponin) score

Comparator

HEART score and TIMI score

Outcome

90-day major adverse cardiac events (MACE)composite

Main Result

Effect estimate: AUC 0.806

Limitations

Relatively low sensitivity limits its utility as a standalone screening tool.
relatively low sensitivity, which limits its utility as a standalone screening tool

Cite This Study

synapsesocial.com/papers/6a5b178d18557b26c2039b2d https://doi.org/10.1186/s12873-026-01685-7

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