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This research aims to explore the anti-tumor effects of 8-gingerol in ovarian cancer, focusing on its mechanisms of action.

8-gingerol from Zingiber officinale induces ER stress-mediated ferroptosis and apoptosis in ovarian cancer involving TRPV1 activation

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Randomized trial evaluates 8-gingerol's effects on ovarian cancer, indicating its potential as a new treatment strategy.

This research aims to explore the anti-tumor effects of 8-gingerol in ovarian cancer, focusing on its mechanisms of action.
Examined cell viability, GSH levels, caspase-3 activity, LDH release, ROS generation, and MDA levels in ovarian cancer cell lines.
Investigated molecular mechanisms involving TRPV1-PLCγ-NOX4 and PERK-ATF3-JMJD2C-SLC7A11-GPX4 pathways.
Assessed therapeutic efficacy of 8-gingerol in vivo using a xenograft mouse model.
8-gingerol significantly reduced cell viability and intracellular GSH levels, while increasing caspase-3 activity and LDH release.
Treatment led to increased ROS production and MDA levels, associated with inhibited tumor growth in vivo.
Induced cell death was mediated by TRPV1 activation and Ca2+ accumulation, confirming 8-gingerol's therapeutic potential.

Tae Woo Kim (2026) studied this question.

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