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July 12, 2026BMC Pulmonary MedicineOpen Access

The efficacy-invasiveness trade-off: a retrospective cohort comparison of surgical operation and endobronchial valves for refractory lung bullae disease

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Authors

HLHui LiZZZejin ZhangHNHaoning Nan

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Overview

Retrospective cohort comparison evaluates outcomes of surgical operations versus endobronchial valves for lung bullae, suggesting individualized treatment plans.

Key Points

  • This study aims to compare the long-term efficacy and safety of surgical operations versus endobronchial valves for refractory lung bullae.
  • Retrospective cohort analysis of 673 patients with refractory bullae disease from two Chinese centers.
  • Propensity score matching was applied to control for confounding factors.
  • Outcomes analyzed include perioperative metrics, 1-year efficacy, and long-term recurrence-free survival.
  • SO led to significant improvements in lung function (adjusted mean FEV1%: -9.71%, p < 0.001) and exercise capacity (adjusted mean 6MWD: -53.04 m, p < 0.001).
  • After matching, SO had higher 2-year recurrence-free survival rate (86.5%) compared to EBV (70.0%), with HR for EBV at 2.48 (p < 0.001).
  • EBV resulted in lower complication rates (OR = 0.33) but was associated with higher long-term costs (mean increase ¥104,502).

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a5331ce4f7abc118adeda68https://doi.org/10.1186/s12890-026-04488-5
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Also Consider

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  1. 1The effect of bronchoscopic lung volume reduction using endobronchial valves for individuals with emphysematous COPD: a protocol for a systematic review and meta-analysis2026
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  3. 3Endobronchial Valve Treatment for Persistent Air Leak and Endoscopic Lung Volume Reduction of Native Lung in a Single Lung Transplant Recipient: A Case Report and Literature Review2025 · 1 citations
  4. 4Bronchoscopic Lung Volume Reduction with Endobronchial Valves: A Consensus Statement on Practical Aspects of Patient Selection and Periprocedural Management2025 · 3 citations
  5. 5Hybrid Lung Voume Reduction: A Case Series on Combining Surgical and Bronchoscopic Treatment2025