Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 11, 2026HematologyOpen Access

Integrated multi-omics analysis identifies prognostic risk genes and constructs a predictive signature in diffuse large B-cell lymphoma

View Full Paper
Ask AI
Bookmark
Share

Authors

SKSufei KuangQLQixin Liu

Discussion

Loading...

Member takes

Overview

Randomized trial identifies 15 prognostic genes in diffuse large B-cell lymphoma, suggesting new treatment targets.

Key Points

  • The aim is to identify pathogenic genes associated with diffuse large B-cell lymphoma (DLBCL) and construct a predictive signature.
  • Identified DLBCL risk genes through expression quantitative trait loci-Mendelian randomization (eQTL-MR).
  • Conducted Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses for biological functions.
  • Analyzed single-cell RNA sequencing (scRNA-seq) data and immune infiltration.
  • Identified 15 genes associated with DLBCL pathogenesis and prognosis with an Area Under the Curve (AUC) of 0.787.
  • GO and KEGG analyses indicated significant pathways including NF-κB signal transduction.
  • Confirmed the role of immune infiltration in the progression of DLBCL.

Cite This Study

Kuang et al. (2026) studied this question.

synapsesocial.com/papers/6a51df9fc18d7f28ca500928https://doi.org/10.1080/16078454.2026.2700818
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exploration of biomarkers for predicting the prognosis of patients with diffuse large B-cell lymphoma by machine-learning analysis2025 · 1 citations
  2. 2Risk Model Based On Neutrophil-Related Genes Constructs to Assess Prognosis and Immune Landscape in Diffuse Large B-Cell Lymphoma2025
  3. 3Uncovering survival-linked genes in DLBCL: A transcriptomic analysis of 1,311 patients2025
  4. 4Real-world patient-based next-generation sequencing assessments identify a high-risk subgroup and associated gene signature in diffuse large B cell lymphoma2025
  5. 5Establishment of a prognostic model for diffuse large B-cell lymphoma based on mitochondrial energy metabolism-related genes2025