Key result
Moderately elevated BP is linked to ~0.3% lower mortality risk versus severely elevated BP.
Why the study?
Does moderately elevated blood pressure (SBP 140-159/90-99 mmHg) reduce mortality and cardiovascular events compared to severely elevated blood pressure (SBP ≥160/≥100 mmHg) in older adults presenting to the emergency department?
Population
383,658 adults aged ≥ 65 years presenting to the emergency department with essential hypertension without…
Comparison
Moderately elevated blood pressure vs Severely elevated blood pressure
Design
Cohort
Follow-up
5 years
Authors
Loading...
Stage 1 HTN in older ED patients was associated with modestly lower MACE risk than stage 2; leaves open optimal targets pending RCTs.
Cohort (n=383,658)
Yes
Does moderately elevated blood pressure (SBP 140-159/90-99 mmHg) reduce mortality and cardiovascular events compared to severely elevated blood pressure (SBP ≥160/≥100 mmHg) in older adults presenting to the emergency department?
Absolute Risk Reduction: 0.33 (95% CI 0.15–0.51)
Absolute Risk Reduction: 0.33%
p-value: p=< 0.0001
In older adults presenting to the ED, moderately elevated BP (SBP 140-159 mmHg) is associated with statistically significant but clinically small (<1% absolute risk difference) reductions in mortality and cardiovascular events compared to severely elevated BP (SBP ≥160 mmHg).
Patel et al. (2026) conducted a cohort in Essential hypertension (n=383,658). Moderately elevated blood pressure (SBP 140–159 mmHg and DBP 90–99 mmHg) vs. Severely elevated blood pressure (SBP ≥ 160 mmHg and DBP ≥ 100 mmHg) was evaluated on All-cause mortality over 5 years (RD 0.33%, 95% CI 0.15-0.51, p=< 0.0001). Moderately elevated BP (SBP 140-159 mmHg) was associated with a lower risk of all-cause mortality compared to severely elevated BP (SBP ≥160 mmHg) (ARR 0.33%; 95% CI 0.15-0.51%; p<0.0001).
Synapse has enriched one closely related paper. Consider it for comparative context: