Population
Patients with mechanical prosthetic valve thrombosis (PVT)
Design
Review
Key result
Immune dysregulation, genetic modifiers, transient physiologic states, and localized hemodynamic abnormalities are underrecognized contributors to mechanical prosthetic valve thrombosis.
Authors
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May prompt broader PVT evaluation beyond anticoagulation; challenges consensus on conventional drivers and leaves open alternative mechanisms.
This review highlights the limitations of an anticoagulation-centered paradigm for mechanical prosthetic valve thrombosis and supports a more individualized, mechanism-oriented approach to diagnosis and prevention.
Kalçık et al. (2026) conducted a review in Mechanical prosthetic valve thrombosis (PVT). Non-conventional mechanisms (immune, genetic, hematologic, hormonal, hemodynamic) was evaluated. Immune dysregulation, genetic modifiers, transient physiologic states, and localized hemodynamic abnormalities are underrecognized contributors to mechanical prosthetic valve thrombosis.