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July 9, 2026Journal of Clinical MedicineOpen Access

Cardiac CT integrates cardiovascular phenotyping to shift clinical decisions toward patient-specific precision strategies.

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Design

Review

Key result

Cardiac computed tomography serves as an integrative platform for cardiovascular phenotyping, shifting clinical decision-making toward precision-guided patient-specific strategies.

Authors

GNGianluigi NapoliDTDonatella TansellaMSMaria Teresa Savo

Discussion

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Overview

CT integration of CAC and plaque data may refine risk stratification; leaves open prospective validation before changing practice.

Key Points

  • The study aims to assess the evolution of cardiac CT technology in enhancing risk assessment and management of coronary artery disease.
  • Evaluated coronary artery calcium scoring and coronary CT angiography in assessing coronary artery disease.
  • Integrated CT-derived biomarkers and physiological measurements to improve decision-making.
  • Analyzed the use of artificial intelligence in refining diagnostic capabilities of cardiac CT.
  • Coronary artery calcium quantification significantly improves risk estimation in asymptomatic individuals (P<0.05).
  • CT-derived fractional flow reserve increased identification of flow-limiting stenoses, reducing unnecessary procedures by 30%.
  • Perivascular fat attenuation index revealed new insights into vascular inflammation, indicating residual risk in patients without significant stenosis.

PICO

P
Population
Cardiovascular disease
I
Intervention / Comparator
Cardiac computed tomography

Cardiac CT has evolved into an integrative platform for cardiovascular phenotyping, shifting clinical decision-making toward precision-guided patient-specific strategies.

Cite This Study

Napoli et al. (2026) conducted a review in Cardiovascular disease. Cardiac computed tomography was evaluated. Cardiac computed tomography serves as an integrative platform for cardiovascular phenotyping, shifting clinical decision-making toward precision-guided patient-specific strategies.

synapsesocial.com/papers/6a4f3a702b81a944af574b80https://doi.org/10.3390/jcm15135313
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  1. 1Redefining cardiovascular risk stratification: The evolving role of coronary CTA2025
  2. 2Cardiac computed tomography beyond anatomical coronary artery disease assessment: A contemporary review2025 · 1 citations
  3. 3Clinical Applications of Cardiac Computed Tomography: A Focused Review for the Clinical Cardiologists2025 · 1 citations
  4. 4Coronary computed tomography angiography: modern capabilities of the technique and place in everyday clinical practice2025
  5. 5Computed Tomography and Coronary Plaque Analysis2025 · 4 citations