Key result
Highest physical activity fragmentation linked to ~23% greater composite CVD risk versus lowest quartile.
Why the study?
Does higher physical activity fragmentation increase the risk of incident cardiovascular diseases in adults?
Population
77,571 participants with accelerometer-measured physical activity data from the UK Biobank
Comparison
Highest quartile of active-to-inactive… vs Lowest quartile of active-to-inactive transition…
Design
Cohort
Follow-up
median 7.7 years
Authors
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Activity transition monitoring may aid CVD risk stratification; leaves open causal effects and needs prospective trials.
Cohort (n=77,571)
Yes
Does higher physical activity fragmentation increase the risk of incident cardiovascular diseases in adults?
Hazard Ratio: 1.23 (95% CI 1.14–1.32)
Higher physical activity fragmentation, independent of total physical activity volume, is associated with an increased risk of incident cardiovascular diseases.
Dong et al. (2026) conducted a cohort in Cardiovascular diseases (n=77,571). Highest quartile of active-to-inactive transition probability (AITP) vs. Lowest quartile of AITP was evaluated on Composite cardiovascular disease (heart failure, atrial fibrillation, and coronary heart disease) (HR 1.23, 95% CI 1.14-1.32). The highest quartile of physical activity fragmentation (AITP) was associated with an increased risk of composite cardiovascular disease compared to the lowest quartile (HR 1.23; 95% CI 1.14-1.32).
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