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July 7, 2026Journal of Cardiovascular ImagingOpen Access

Dual-chamber pacing linked to early deterioration in myocardial deformation, worsening RVGLS by ~3%.

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Why the study?

Does dual-chamber pacemaker implantation alter echocardiographic measures of ventricular and atrial function in patients requiring pacing?

Population

57 patients who underwent dual-chamber pacemaker implantation and had transthoracic echocardiography…

Comparison

Dual-chamber pacemaker implantation vs Baseline (pre-implantation echocardiography)

Design

Cohort

Key result

Dual-chamber pacemaker implantation was associated with early deterioration in myocardial deformation, particularly RVGLS (worsened by 3.10%; P=0.012) and LAScd (declined by 3.74%; P=0.032).

Authors

SSSi Ling SohIWIan WeeRMRowina Lynne Murray Binti Jeffery Murray

Discussion

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Overview

Early strain changes after dual-chamber pacing should not alter practice; leaves open long-term prognostic relevance.

Key Points

  • This study aims to evaluate echocardiographic changes following dual-chamber pacemaker implantation, focusing on ventricular mechanics and valvular function.
  • Retrospective single-center study conducted in 2022.
  • Assessment of echocardiographic parameters before and after pacemaker implantation in 57 patients.
  • Analysis included left ventricular ejection fraction, strain measures, and tricuspid regurgitation severity.
  • Mean left ventricular ejection fraction declined from 59.6% to 55.8%, P=0.051.
  • Right ventricular global longitudinal strain worsened by 3.10%, P=0.012, and left atrial conduit strain declined by 3.74%, P=0.032.
  • Tricuspid regurgitation severity showed no significant shift, P=0.678.

Study Design

Type

Observational (n=57)

Multicenter

No

Structured PICO

Does dual-chamber pacemaker implantation alter echocardiographic measures of ventricular and atrial function in patients requiring pacing?

P
Population
57 patients who underwent dual-chamber pacemaker implantation and had transthoracic echocardiography performed before and after implantation in 2022.
E
Exposure
Dual-chamber pacemaker implantation
C
Comparator
Baseline (pre-implantation echocardiography)
O
Outcome
Changes in left ventricular ejection fraction (LVEF), ventricular and atrial functional parameters, strain-derived measures, and tricuspid regurgitation (TR) severitysurrogate

Main Result

Mean Difference: -3.76 (95% CI -7.45–0.08)

Absolute Event Rate: 55.8% vs 59.6%

p-value: p=0.051

Dual-chamber pacemaker implantation is associated with early subclinical deterioration in right ventricular and left atrial strain, despite preserved conventional systolic parameters.

Cite This Study

Soh et al. (2026) conducted an observational in Dual-chamber pacemaker implantation (n=57). Dual-chamber pacemaker implantation vs. Baseline (before implantation) was evaluated on Change in left ventricular ejection fraction (LVEF) (MD -3.76%, 95% CI -7.45 to 0.08, p=0.051). Dual-chamber pacemaker implantation was associated with early deterioration in myocardial deformation, particularly RVGLS (worsened by 3.10%; P=0.012) and LAScd (declined by 3.74%; P=0.032).

synapsesocial.com/papers/6a4c9687331bc25c9e5f3fb4https://doi.org/10.1186/s44348-026-00077-6
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