Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 5, 2026Indian Journal of Public HealthOpen Access

Advancing liver fibrosis is linked to greater CIMT in patients with NAFLD.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does liver fibrosis severity correlate with carotid intima-media thickness in patients with NAFLD?

Population

Patients with nonalcoholic fatty liver disease undergoing fibroscan for the evaluation of NAFLD at Dayanand…

Design

Cross-sectional

Key result

Advancing liver fibrosis assessed by transient elastography was significantly associated with increased right and left carotid intima-media thickness (P=0.001) in patients with NAFLD.

Authors

YGYogesh Kumar GuptaSNSahil NohriaVMVarun Mehta

Discussion

Loading...

Member takes

Overview

Association of FibroScan stiffness with carotid IMT in NAFLD is hypothesis-generating; prospective studies needed before clinical adoption.

Key Points

  • The study aims to determine the relationship between liver stiffness and carotid intima-media thickness in patients with nonalcoholic fatty liver disease.
  • Included NAFLD patients undergoing FibroScan and carotid intimal-medial thickness measurements.
  • Measured CIMT using B-mode ultrasound on a Philips Affiniti 50C USG machine.
  • Assessed liver fibrosis based on severity grades (F0-F3) and corresponding ultrasound findings.
  • CIMT increased significantly with advancing fibrosis stages; P=0.001 for both sides.
  • Serum cholesterol and triglyceride levels elevated while HDL cholesterol decreased with fibrosis (P=0.005).
  • Grade III fatty liver observed in 70.4% of F3 patients, correlating increased severity with atherosclerosis risk.

Study Design

Type

Observational

Multicenter

No

Structured PICO

Does liver fibrosis severity correlate with carotid intima-media thickness in patients with NAFLD?

P
Population
Patients with nonalcoholic fatty liver disease undergoing fibroscan and carotid intimal-medial thickness evaluation.
E
Exposure
Liver stiffness assessment using FibroScan (transient elastography)
O
Outcome
Correlation of liver stiffness (fibrosis stage) with carotid intima-media thickness (CIMT)surrogate

Main Result

p-value: p=0.001

Higher grades of liver fibrosis assessed by transient elastography correlate with increased carotid intima-media thickness, suggesting it can serve as a risk marker for atherosclerosis in NAFLD patients.

Cite This Study

Gupta et al. (2026) conducted an observational in Nonalcoholic fatty liver disease (NAFLD). Liver fibrosis severity vs. Lower grades of fibrosis was evaluated on Carotid intima-media thickness (CIMT) (p=0.001). Advancing liver fibrosis assessed by transient elastography was significantly associated with increased right and left carotid intima-media thickness (P=0.001) in patients with NAFLD.

synapsesocial.com/papers/6a49f6c9f5d1d45b28800fc5https://doi.org/10.4103/ijph.ijph_824_25
View Full Paper
Ask AI
Bookmark
Share