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July 4, 2026Journal of Parenteral and Enteral Nutrition

Association between blood phosphorus level and clinical outcomes in critically ill patients: A systematic review and meta‐analysis

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Authors

PIPardis IrandoostMAMohammad AnsariMLMohammad Niakan Lahiji

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Overview

Systematic review finds links between phosphorus levels and adverse outcomes in ICU patients, suggesting monitoring is crucial.

Key Points

  • This review aims to explore how blood phosphorus levels impact clinical outcomes in critically ill patients.
  • Conducted systematic review and meta-analysis per PRISMA guidelines.
  • Included adult ICU patients with reported blood phosphorus levels and clinical outcomes.
  • Assessed risk of bias using the ROBINS-I tool.
  • Hypophosphatemia not linked to ICU or hospital mortality but prolonged ICU stay (+1.53 days) and mechanical ventilation (+1.54 days).
  • Hyperphosphatemia associated with increased ICU mortality (RR: 1.21, 95% CI: 1.13-1.29; P < 0.001) and hospital mortality (RR: 2.10, 95% CI: 1.49-2.95; P < 0.001).
  • Evidence quality was low to very low, with high heterogeneity noted across studies.

Cite This Study

Irandoost et al. (2026) studied this question.

synapsesocial.com/papers/6a48a6b689561a0c2d78ea1dhttps://doi.org/10.1002/jpen.70115
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  1. 1Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement2009 · 83,714 citations