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July 4, 2026Journal of Brown Hospital Medicine

Infective endocarditis shifts to S. aureus, with higher mortality in prosthetic valve and device patients.

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Population

Patients with infective endocarditis, including those with prosthetic valves or intracardiac devices

Design

Review

Key result

Infective endocarditis epidemiology has shifted to Staphylococcus aureus, with higher mortality and treatment failure rates observed in patients with prosthetic valves or intracardiac devices.

Authors

FBFranck Mbuntcha BogniJGJulia S. GilletteVSVijairam Selvaraj

Discussion

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Overview

Supports heightened S. aureus suspicion in IE; leaves open optimal management of prosthetic/device infections.

Key Points

  • To review the management strategies for infective endocarditis and identify changes in pathogen prevalence and treatment outcomes.
  • Conducted a scoping review of literature on infective endocarditis management.
  • Examined shifts in predominant pathogens and implications for treatment.
  • Analyzed complications related to prosthetic valves and intracardiac devices.
  • Staphylococcus aureus is now the most common cause of infective endocarditis, overtaking viridans streptococci.
  • Infections associated with prosthetic valves have higher mortality and complications compared to native valve infections.
  • Optimal treatment hinges on targeted antimicrobial therapy based on blood culture and susceptibility data.

Structured PICO

P
Population
Patients with infective endocarditis, including those with prosthetic valves or intracardiac devices
E
Exposure
Management of infective endocarditis (targeted antimicrobial therapy)

This scoping review highlights the shifting epidemiology of infective endocarditis toward Staphylococcus aureus and emphasizes the complexities of managing infections involving prosthetic valves or intracardiac devices.

Cite This Study

Bogni et al. (2026) conducted a review in Infective endocarditis. Management of Infective Endocarditis was evaluated. Infective endocarditis epidemiology has shifted to Staphylococcus aureus, with higher mortality and treatment failure rates observed in patients with prosthetic valves or intracardiac devices.

synapsesocial.com/papers/6a48a47889561a0c2d78dc69https://doi.org/10.56305/001c.162066
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