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July 4, 2026Journal of Clinical Apheresis

The Role of Therapeutic Apheresis in the Management of Rheumatoid Arthritis A Systematic Review and Meta‐Analysis

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Authors

LZL N ZhaoSMShaohui MaSCSiyi Chen

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Overview

Systematic review and meta-analysis assess therapeutic apheresis efficacy in rheumatoid arthritis, suggesting specific techniques may be beneficial.

Key Points

  • This review aims to evaluate the efficacy of therapeutic apheresis in managing refractory rheumatoid arthritis.
  • Systematic retrieval of studies from PubMed, Web of Science, and Cochrane Library up to December 2024.
  • Inclusion of 16 studies (10 RCTs, 6 case series) assessing apheresis interventions for RA treatment.
  • Meta-analysis performed using a random-effects model; methodological quality assessed with ROB2 and JBI checklist.
  • Meta-analysis of 8 RCTs showed no significant benefit of apheresis as standalone therapy; HAQ SMD -1.02 (95% CI: -2.15 to 0.11).
  • DFPP showed most consistent benefits when adjunct to DMARDs; ESR pooled MD -22.32 (95% CI: -61.74 to 17.11).
  • TPE and LPE had limited efficacy and higher adverse events; overall evidence certainty was very low to low.

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/6a48a3cb89561a0c2d78d86chttps://doi.org/10.1002/jca.70153
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