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July 4, 2026ZooKeysOpen Access

Anti-collagenase and anti-elastase activities of Ardisia elliptica Thunb. extract: in vitro and molecular docking insights

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Authors

IRIdah RosidahNNNgatinem NgatinemASAgus Himawan Subiantoro

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Overview

Randomized trial evaluates anti-aging effects of Ardisia elliptica extract in vitro, highlighting its potential for skincare products.

Key Points

  • This study aims to investigate the antioxidant and enzyme-inhibitory activities of Ardisia elliptica extract and elucidate its molecular mechanisms.
  • Extracted various plant parts using ultrasound-assisted extraction and maceration;
  • Conducted phytochemical analysis with LC-HRMS for metabolite profiling;
  • Measured antioxidant activities and enzyme inhibition through DPPH, ABTS assays, and determined IC50 values.
  • Leaf extract showed IC50 values of 54.21 μg/mL for DPPH and 43.73 μg/mL for ABTS antioxidant assays;
  • Significant collagenase inhibition with IC50 of 104.11 μg/mL and elastase inhibition with IC50 of 294.67 μg/mL;
  • Molecular docking indicated bilobol and α-linolenic acid as strong collagenase inhibitors with high MolDock scores.

Cite This Study

Rosidah et al. (2026) studied this question.

synapsesocial.com/papers/6a48a29489561a0c2d78d1adhttps://doi.org/10.3897/pharmacia.73.e193264
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