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July 2, 2026PLoS ONEOpen Access

T2DM in HF patients is linked to a ~16% higher HF hospitalization count.

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Why the study?

Does Type 2 diabetes mellitus increase heart failure hospitalization burden in adult patients with heart failure?

Population

137,785 adult patients hospitalized with heart failure from a nationwide EHR database.

Comparison

Presence of Type 2 diabetes mellitus (T2DM) vs Absence of Type 2 diabetes mellitus (T2DM)

Design

Cohort

Follow-up

19 years (database coverage)

Key result

Type 2 diabetes mellitus in heart failure patients was associated with a higher mean HF hospitalization count compared to those without diabetes (2.81 vs. 2.42, p<0.001).

Authors

ASAllison K. ShayWTWei TaoSPSoumya Patnaik

Discussion

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Member takes

Overview

May warrant enhanced HF surveillance in diabetes; leaves open whether glycemic optimization reduces recurrent hospitalizations.

Study Design

Type

Cohort (n=137,785)

Multicenter

Yes

Structured PICO

Does Type 2 diabetes mellitus increase heart failure hospitalization burden in adult patients with heart failure?

P
Population
137,785 adult patients hospitalized with heart failure from a nationwide EHR database over 19 years, stratified by type 2 diabetes status.
E
Exposure
Presence of Type 2 diabetes mellitus (T2DM)
C
Comparator
Absence of Type 2 diabetes mellitus (T2DM)
O
Outcome
HF-related hospitalization count, length of first HF hospitalization, and age at first HF hospitalizationhard clinical

Main Result

Absolute Event Rate: 2.81% vs 2.42%

p-value: p=<0.001

Type 2 diabetes is associated with a higher burden of heart failure hospitalizations, longer hospital stays, and earlier onset of hospitalization, particularly in patients with diastolic heart failure.

Cite This Study

Shay et al. (2026) conducted a cohort in Heart failure (n=137,785). Type 2 diabetes mellitus vs. Without type 2 diabetes mellitus was evaluated on Heart failure hospitalization count (p=<0.001). Type 2 diabetes mellitus in heart failure patients was associated with a higher mean HF hospitalization count compared to those without diabetes (2.81 vs. 2.42, p<0.001).

synapsesocial.com/papers/6a486f061f52bd9ca6721ab0https://doi.org/10.1371/journal.pone.0351763
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Type 2 diabetes mediated heart failure: focus on early recognition and clinical strategies2025 · 3 citations