What is the clinical evidence from this study?

Study design: Cohort. Population: Hypertrophic obstructive cardiomyopathy (HOCM) (n=1993). Intervention: Mitral valve repair vs. Mitral valve replacement. Primary outcome: 10-year survival (p=0.002).

What question did this study set out to answer?

To explore indications and strategies for mitral regurgitation in patients undergoing septal myectomy for hypertrophic obstructive cardiomyopathy.

July 3, 2026Journal of the American College of Cardiology

Mitral valve repair in HOCM is linked to ~25% higher absolute 10-year survival than replacement.

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Key result

Among HOCM patients requiring concomitant mitral valve surgery, mitral valve repair was associated with superior 10-year survival compared with replacement (80.0% vs. 55.2%; p=0.002).

Authors

JHJoonhwa Hong HSHartzell V. Schaff RNRick A. Nishimura

Discussion

Member takes

Overview

Septal myectomy was associated with marked MR reduction in HOCM; leaves open need for prospective confirmation of durability and survival.

Key Points

To explore indications and strategies for mitral regurgitation in patients undergoing septal myectomy for hypertrophic obstructive cardiomyopathy.
Retrospective review of 2,107 septal myectomy operations between 1993 and 2014 at Mayo Clinic.
Excluded patients with prior mitral valve surgery or apical hypertrophic cardiomyopathy.
Evaluated pre-operative and post-operative mitral regurgitation grades.
57.5% of operations had pre-operative mitral regurgitation grade ≥3.
Post-operative echocardiography showed reduction of MR grade ≥3 from 54.3% to 1.7% (p=0.001).
Among 174 patients with concomitant surgery, MV repair led to 10-year survival rates of 80.0%, versus 55.2% for replacement (p=0.002).

Study Design

Type

Cohort (n=1,993)

Multicenter

PICO

Population

1,993 adults with hypertrophic obstructive cardiomyopathy undergoing septal myectomy, evaluated for mitral regurgitation resolution and long-term survival.

Exposure / Comparator

Mitral valve repair vs Mitral valve replacement

Primary Outcome

10-year survival, p=0.002

Main Result

Absolute Event Rate: 80% vs 55.2%

p-value: p=0.002

Cite This Study

Hong et al. (2016) conducted a cohort in Hypertrophic obstructive cardiomyopathy (HOCM) (n=1,993). Mitral valve repair vs. Mitral valve replacement was evaluated on 10-year survival (p=0.002). Among HOCM patients requiring concomitant mitral valve surgery, mitral valve repair was associated with superior 10-year survival compared with replacement (80.0% vs. 55.2%; p=0.002).

synapsesocial.com/papers/6a47d2ecad3d0ceaee1001a5 https://doi.org/10.1016/j.jacc.2016.07.735

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July 3, 2026Journal of the American College of Cardiology

Mitral valve repair in HOCM is linked to ~25% higher absolute 10-year survival than replacement.

View Full Paper

Ask AI

Bookmark

Key result

Among HOCM patients requiring concomitant mitral valve surgery, mitral valve repair was associated with superior 10-year survival compared with replacement (80.0% vs. 55.2%; p=0.002).

Authors

JHJoonhwa Hong HSHartzell V. Schaff RNRick A. Nishimura

Discussion

Member takes

Overview

Septal myectomy was associated with marked MR reduction in HOCM; leaves open need for prospective confirmation of durability and survival.

Key Points

To explore indications and strategies for mitral regurgitation in patients undergoing septal myectomy for hypertrophic obstructive cardiomyopathy.
Retrospective review of 2,107 septal myectomy operations between 1993 and 2014 at Mayo Clinic.
Excluded patients with prior mitral valve surgery or apical hypertrophic cardiomyopathy.
Evaluated pre-operative and post-operative mitral regurgitation grades.
57.5% of operations had pre-operative mitral regurgitation grade ≥3.
Post-operative echocardiography showed reduction of MR grade ≥3 from 54.3% to 1.7% (p=0.001).
Among 174 patients with concomitant surgery, MV repair led to 10-year survival rates of 80.0%, versus 55.2% for replacement (p=0.002).

Study Design

Type

Cohort (n=1,993)

Multicenter

PICO

Population

1,993 adults with hypertrophic obstructive cardiomyopathy undergoing septal myectomy, evaluated for mitral regurgitation resolution and long-term survival.

Exposure / Comparator

Mitral valve repair vs Mitral valve replacement

Primary Outcome

10-year survival, p=0.002

Main Result

Absolute Event Rate: 80% vs 55.2%

p-value: p=0.002

Cite This Study

synapsesocial.com/papers/6a47d2ecad3d0ceaee1001a5 https://doi.org/10.1016/j.jacc.2016.07.735

View Full Paper

Ask AI

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