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July 3, 2026Journal of the American College of Cardiology

Structural MV abnormalities contribute to SAM in HCM and can be imaged and surgically repaired.

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Key result

Structural abnormalities of the mitral valve contribute to systolic anterior motion in hypertrophic cardiomyopathy and can be detected by imaging and repaired surgically.

Authors

MSMark V. SherridSBSandhya K. BalaramBKBette Kim

Discussion

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Key expert perspectives

Captured external expert commentary on this paper, strongest first. Original sources are linked where available.

DGDaniel G. SwistelCardiothoracic surgeon, NYU School of Medicine

“For the subset of patients with HCM and leaflet elongation but minimal septal hypertrophy, myectomy is often not adequate for complete relief. Our procedure offers added insurance against negative outcomes for these individuals.”

NYU Langone HealthNews Coverage
SRSteve R. OmmenCardiologist, Mayo Clinic

“The anatomic hypertrophy of the ventricular septum, coupled with anatomic abnormalities of the mitral valve cause abnormal flow vectors that push the mitral valve into the outflow tract resulting in dynamic obstruction.”

Mayo ClinicEditorial

Overview

May inform mitral assessment in obstructive HCM; leaves open optimal surgical strategies pending prospective data.

Key Points

  • The aim is to explore mitral valve abnormalities in obstructive hypertrophic cardiomyopathy and their contributions to disease pathology.
  • Critical review of imaging techniques including transthoracic and transesophageal echocardiography and cardiac magnetic resonance.
  • Assessment of surgical interventions for mitral valve abnormalities.
  • Identified malformations in mitral valve leaflets and submitral apparatus, impacting systolic anterior motion.
  • Surgical repair of mitral abnormalities has become more common due to their role in SAM pathophysiology.

PICO

P
Population
Obstructive Hypertrophic Cardiomyopathy
E
Exposure / Comparator
Imaging and surgical repair of mitral valve abnormalities

Cite This Study

Sherrid et al. (2016) conducted a review in Obstructive Hypertrophic Cardiomyopathy. Imaging and surgical repair of mitral valve abnormalities was evaluated. Structural abnormalities of the mitral valve contribute to systolic anterior motion in hypertrophic cardiomyopathy and can be detected by imaging and repaired surgically.

synapsesocial.com/papers/6a47d2ebad3d0ceaee1001a3https://doi.org/10.1016/j.jacc.2016.01.071
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