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July 2, 2026Neurological Research

Predictive ability of cardiac biomarkers for early risk stratification and 3-month functional outcomes after reperfusion therapy in acute ischemic stroke

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Why the study?

Do baseline serum cardiac biomarkers predict functional outcomes and risk in patients with acute ischemic stroke undergoing reperfusion therapy?

Population

433 patients with acute ischemic stroke treated with intravenous thrombolysis, mechanical thrombectomy, or…

Design

Cohort

Follow-up

3 months

Key result

Elevated baseline hs-cTnT (>10.5 pg/mL) and LDH (>200 U/L) independently predicted poor 3-month functional outcomes in acute ischemic stroke patients (OR 1.685 and 1.845, respectively; p<0.05).

Authors

IAIşıl Kalyoncu AslanLRLeyla RamazanoğluOKOzan Keske

Discussion

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Overview

May aid post-reperfusion risk stratification in AIS; hypothesis-generating and requires prospective validation before clinical adoption.

Key Points

  • This study aims to assess how baseline serum cardiac biomarkers can predict functional outcomes in patients with acute ischemic stroke after reperfusion therapy.
  • Retrospective cohort of 433 AIS patients treated with IVT, MT, or combined therapy.
  • Analyzed serum levels of lactate dehydrogenase, creatine kinase, NT-proBNP, and hs-cTnT.
  • Used multivariate logistic regression to identify independent risk factors for poor outcomes.
  • Hs-cTnT > 10.5 pg/mL predicts poor discharge prognosis (OR: 1.725, p < 0.05).
  • Optimal cut-off for predicting poor 3-month prognosis: LDH > 200 U/L (p = 0.003), hs-cTnT > 10.5 pg/mL (p = 0.007).
  • Baseline NIHSS, stroke etiology, LDH (>200 U/L, OR: 1.845, p < 0.05), and hs-cTnT (>10.5 pg/mL, OR: 1.685, p < 0.05) are independent risk factors for poor outcomes.

Study Design

Type

Cohort (n=433)

Structured PICO

Do baseline serum cardiac biomarkers predict functional outcomes and risk in patients with acute ischemic stroke undergoing reperfusion therapy?

P
Population
433 patients with acute ischemic stroke treated with reperfusion therapy, followed for 3 months to assess functional outcomes.
E
Exposure
Baseline serum cardiac biomarkers (lactate dehydrogenase, creatine kinase, N-terminal pro-brain natriuretic peptide, and high-sensitivity cardiac troponin T) measured at emergency department admission.
O
Outcome
Functional outcomes at discharge and 3 months, stroke severity, hemorrhagic transformation, and mortality.hard clinical

Main Result

Odds Ratio: 1.685

p-value: p=<0.05

Elevated baseline hs-cTnT and LDH levels independently predict poor 3-month functional outcomes in patients with acute ischemic stroke undergoing reperfusion therapy.

Cite This Study

Aslan et al. (2026) conducted a cohort in Acute ischemic stroke (n=433). Elevated baseline serum cardiac biomarkers (hs-cTnT >10.5 pg/mL and LDH >200 U/L) vs. Lower biomarker levels was evaluated on Poor 3-month prognosis (OR 1.685, p=<0.05). Elevated baseline hs-cTnT (>10.5 pg/mL) and LDH (>200 U/L) independently predicted poor 3-month functional outcomes in acute ischemic stroke patients (OR 1.685 and 1.845, respectively; p<0.05).

synapsesocial.com/papers/6a45ffd19ed1343031310137https://doi.org/10.1080/01616412.2026.2694662
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