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June 28, 2026Clinical Case ReportsOpen Access

Belumosudil for Long‐Standing Refractory Chronic Graft‐Versus‐Host Disease: A Two‐Patient Case Report

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Authors

MKMihee KimHJHo Cheol JangGSGa‐Young Song

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Overview

Case report shows improvement in symptoms of chronic GVHD, suggesting possible extended use.

Key Points

  • This report aims to explore the effects of belumosudil on refractory chronic graft-versus-host disease (GVHD) over a long duration.
  • Two patients with long-standing fibrotic chronic GVHD treated with belumosudil.
  • Monitoring of patient-reported outcomes and infection-related hospitalizations.
  • Evaluated NIH organ scores over time.
  • Clinically meaningful improvements reported by both patients.
  • Reduced hospitalizations related to infections.
  • NIH organ scores remained stable while patients experienced benefits.

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/6a40bb1461bb0a67205c6bc8https://doi.org/10.1002/ccr3.73050
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy and safety of the ROCK2-inhibitor belumosudil for chronic gvhd treatment: Multicenter retrospective analysis of a large german-austrian cohort of the belumosudil managed-access program.2025
  2. 2Belumosudil for chronic graft-versus-host disease in children under 12: A retrospective analysis of effectiveness and safety2025
  3. 3Belumosudil in pediatric patients with steroid-refractory chronic graft-versus-host disease2025
  4. 4Response dynamics to belumosudil in chronic graft-versus-host disease: Characterizing late responses and organ-specific response expectations from the rockstar study2025
  5. 5ROCK 2 inhibition with belumosudil for the treatment of chronic graft-versus-host disease: a narrative review2025