What question did this study set out to answer?

To evaluate the effectiveness of peritoneal dialysis in managing severe hyperammonemia in an infant with methylmalonic acidemia.

June 28, 2026CureusOpen Access

Peritoneal Dialysis in Infant Methylmalonic Acidemia: Effective Management Despite Sterile Peritonitis

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Authors

MMMustakiz Z ManirGovernment Medical College UHUtsav HaldarGovernment Medical College NGNiranjan GopalGovernment Medical College

Discussion

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Implication

Case report demonstrates effective management of severe hyperammonemia in an infant using peritoneal dialysis, suggesting clinical viability of this approach.

Key Points

To evaluate the effectiveness of peritoneal dialysis in managing severe hyperammonemia in an infant with methylmalonic acidemia.
Detailed case report of a three-month-old female infant with isolated MMA.
Management involved peritoneal dialysis initiated after metabolic crisis despite conventional treatments.
Complications included culture-negative peritonitis managed with antibiotics and catheter removal.
Ammonia levels decreased from 332 μmol/L to 61 μmol/L after 17 cycles of dialysis.
Metabolic acidosis resolved with bicarbonate level returning to normal on discharge.
Patient was discharged stable on day 23, indicating successful management despite complications.

Cite This Study

Manir et al. (2026) studied this question.

synapsesocial.com/papers/6a40bae361bb0a67205c6a23 https://doi.org/10.7759/cureus.111554

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Implication

Case report demonstrates effective management of severe hyperammonemia in an infant using peritoneal dialysis, suggesting clinical viability of this approach.