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June 27, 2026EP EuropaceOpen Access

VT recurrence occurred in 35% of patients overall, and was significantly higher in non-ischaemic cardiomyopathy (43%) compared to ischaemic cardiomyopathy (24%; p=0.003).

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Why the study?

Does cardiomyopathy type (ischaemic vs non-ischaemic) impact the recurrence of ventricular tachycardia after catheter ablation in patients with structural heart disease and LVEF > 35%?

Population

226 consecutive patients with structural heart disease and moderately impaired left ventricular ejection…

Comparison

Catheter ablation for ventricular tachycardia vs Ischaemic cardiomyopathy versus non-ischaemic…

Design

Cohort

Authors

EWE W WaezsadaMKM K KhalaphTFT F Fink

Discussion

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Overview

Higher VT recurrence in NICM may warrant cautious counseling; leaves open optimal ablation strategies for prospective validation.

Key Points

  • This research aims to assess VT recurrence and predictors in patients with SHD and LVEF > 35%.
  • 226 patients with SHD and LVEF > 35% underwent VT ablation; 89 with ischaemic and 137 with non-ischaemic cardiomyopathy.
  • Baseline characteristics, ablation strategy, procedural success, and outcomes were compared between both groups.
  • 99% of patients had an ICD at the time of ablation.
  • VT recurrence rates were 35% overall, with 43% in NICM and 24% in ICM (p = 0.003).
  • Repeat ablation was necessary in 15% of cases, with 19% in NICM and 9% in ICM (p = 0.04).
  • Only cardiomyopathy type predicted VT recurrence, indicating a complex arrhythmic substrate.

Structured PICO

Does cardiomyopathy type (ischaemic vs non-ischaemic) impact the recurrence of ventricular tachycardia after catheter ablation in patients with structural heart disease and LVEF > 35%?

P
Population
226 consecutive patients with structural heart disease (SHD) and moderately impaired left ventricular ejection fraction (LVEF > 35%) undergoing ventricular tachycardia (VT) ablation, including 89 with ischaemic cardiomyopathy (ICM) and 137 with non-ischaemic cardiomyopathy (NICM). 99% had an ICD at the time of ablation.
I
Intervention
Catheter ablation for ventricular tachycardia
C
Comparator
Ischaemic cardiomyopathy (ICM) versus non-ischaemic cardiomyopathy (NICM)
O
Outcome
Incidence and predictors of VT recurrence after catheter ablation

In patients with structural heart disease and LVEF > 35%, VT ablation yields higher acute success and lower long-term recurrence in ischaemic compared to non-ischaemic cardiomyopathy.

Cite This Study

Waezsada et al. (2026) studied this question.

synapsesocial.com/papers/6a3f97e8125782b61d865aabhttps://doi.org/10.1093/europace/euag105.210
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