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June 27, 2026EP EuropaceOpen Access

At a median follow-up of 407 days, 40/50 patients (80%) were free of any atrial arrhythmia and 46/50 (92%) were free of AF.

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Population

50 consecutive patients undergoing a first ablation procedure for persistent atrial fibrillation, all in AF…

Design

Cohort

Follow-up

median 407 days

Authors

CCC ChaumontTMT MeralASA Savoure

Discussion

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Overview

Demonstrates procedural feasibility in small series; leaves open comparative efficacy versus standard ablation in randomized trials.

Key Points

  • This study aims to evaluate the effectiveness of a personalized ablation strategy for persistent atrial fibrillation by using an algorithm to identify critical ablation areas.
  • Prospective bicentric study involving patients undergoing first ablation for persistent AF from March 2023 to April 2025.
  • Utilization of a 3D anatomical mapping system with an AF-driver detection algorithm to identify arrhythmogenic areas in the left atrium.
  • Follow-up included ECG and 24-hour Holter recordings at 4 and 12 months post-procedure.
  • 34% (17 patients) had sinus rhythm restoration during ablation, primarily after atrial tachycardia organization.
  • Pulsed field ablation targeting identified areas resulted in significant AF slowing with peak L-CL prolongation (171 ± 21 ms to 185 ± 25 ms, p < 0.001).
  • 80% of patients (40/50) were free of any atrial arrhythmia and 92% (46/50) were free of AF by median follow-up of 407 days.

Structured PICO

P
Population
50 consecutive patients undergoing a first ablation procedure for persistent atrial fibrillation, all in AF at the beginning of the procedure. Mean age 66 ± 11 years, 72% male.
I
Intervention
Personalized strategy combining pulmonary vein isolation (PVI) and ablation of putative arrhythmogenic areas identified by an AF-driver detection algorithm using a pentaspline pulsed field ablation (PFA) catheter.
O
Outcome
Freedom from any atrial arrhythmia and freedom from AF at median follow-up of 407 days

A personalized pulsed field ablation strategy combining PVI and algorithm-guided ablation of arrhythmogenic areas was safe and achieved an 80% one-year arrhythmia-free survival rate in patients with persistent AF.

Cite This Study

Chaumont et al. (2026) studied this question.

synapsesocial.com/papers/6a3f97ce125782b61d865a0fhttps://doi.org/10.1093/europace/euag105.477
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