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June 27, 2026EP EuropaceOpen Access

RVOT ablations had higher PVC burden reduction compared to LVOT (81% vs. 63%, p=0.04) and other sites (81% vs. 49%, p=0.001), with 2.3-fold higher odds of burden reduction in logistic regression.

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Why the study?

Does RVOT ablation improve PVC burden reduction compared to LVOT or other sites in patients undergoing idiopathic PVC ablation?

Population

167 patients undergoing idiopathic premature ventricular contraction ablation, mean age 56.5, 53.3% male.

Comparison

Premature ventricular contraction ablation at… vs PVC ablation at the left ventricular outflow…

Design

Cohort

Follow-up

mean 1.4 ± 0.8 years

Authors

BBB BiniamAKA KleinSHS Hansom

Discussion

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Overview

May support RVOT preference for PVC ablation when feasible; leaves open need for randomized confirmation.

Key Points

  • This study aims to evaluate procedural and clinical outcomes of PVC ablation based on the site of origin.
  • Retrospective review of 202 PVC ablation cases from August 2019 to March 2025, excluding cases with missing data or not performed due to risks.
  • Analyzed 167 cases across various ablation sites, including RVOT and LVOT, using logistic regression to evaluate outcomes.
  • Collected data on patient demographics, cardiac function, antiarrhythmic therapy, and PVC burden before and after ablation.
  • Overall success rates were 66.5% for PVC burden reduction and 74.2% for LVEF improvement.
  • RVOT ablations achieved a burden reduction of 81%, significantly higher compared to LVOT (63%) and other sites (49%).
  • Logistic regression showed RVOT ablation had 2.3-fold higher odds of burden reduction than LVOT or non-outflow tract ablations.

Structured PICO

Does RVOT ablation improve PVC burden reduction compared to LVOT or other sites in patients undergoing idiopathic PVC ablation?

P
Population
167 patients undergoing idiopathic premature ventricular contraction (PVC) ablation, mean age 56.5, 53.3% male.
I
Intervention
Premature ventricular contraction (PVC) ablation at the right ventricular outflow tract (RVOT)
C
Comparator
PVC ablation at the left ventricular outflow tract (LVOT) or other non-outflow tract sites
O
Outcome
PVC burden reduction (>80% reduction or post-ablation burden <5%) and Left ventricular ejection fraction (LVEF) improvement (5% increase or post-ablation LVEF > 50%) at 1 year follow-upsurrogate

RVOT ablation for idiopathic PVCs is associated with significantly higher success rates for PVC burden reduction and fewer complications compared to LVOT and non-outflow tract sites.

Limitations

  • Single-center
  • Retrospective design

Cite This Study

Biniam et al. (2026) studied this question.

synapsesocial.com/papers/6a3f97ce125782b61d8659fbhttps://doi.org/10.1093/europace/euag105.1092
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