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June 27, 2026EP EuropaceOpen Access

An ESC SCD risk score of ≥6% was significantly associated with subsequent ICD therapy (OR 11, 95% CI 1.48 to 81.6, p=0.019), whereas genetic variants and extensive LGE scar did not predict ICD therapy.

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Why the study?

Does an ESC sudden cardiac death risk score ≥6% or the presence of a genetic variant predict ventricular arrhythmias and ICD therapy in patients with hypertrophic cardiomyopathy?

Population

73 patients with hypertrophic cardiomyopathy (HCM), mean age 60 ± 12, 63% male.

Design

Cohort

Follow-up

median 5 years 5 months (IQR 3 years - 9 years)

Authors

HMH MooreOBO BasquillGFG Furniss

Discussion

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Overview

May flag higher-risk patients for closer monitoring; hypothesis-generating in small observational data and needs prospective validation.

Key Points

  • This study aims to identify characteristics of hypertrophic cardiomyopathy patients at risk for ventricular arrhythmias after ICD implant and the role of genetic variants.
  • Identified cases of hypertrophic cardiomyopathy using electronic databases.
  • Reviewed electronic health records for demographics, left ventricular outflow tract gradient, SCD risk score, genotype, and ICD therapy.
  • Analyzed predictors of ventricular arrhythmias based on ESC guidelines.
  • 73 patients with HCM identified; 36 underwent genetic testing, with 44% finding genetic variants.
  • The strongest predictor for ICD therapy was an ESC risk score of 6% or more (OR 11, 95% CI 1.48-81.6, p=0.019).
  • An average age at diagnosis was earlier for patients with a genetic variant (46 years) compared to those without (56 years), p=0.007.

Structured PICO

Does an ESC sudden cardiac death risk score ≥6% or the presence of a genetic variant predict ventricular arrhythmias and ICD therapy in patients with hypertrophic cardiomyopathy?

P
Population
73 patients with hypertrophic cardiomyopathy (HCM), mean age 60 ± 12, 63% male.
O
Outcome
Ventricular arrhythmias requiring ICD therapy (shock or anti-tachycardia pacing)hard clinical

An ESC sudden cardiac death risk score of ≥6% is a strong predictor of appropriate ICD therapy in patients with hypertrophic cardiomyopathy, supporting current guideline recommendations for shared decision making.

Limitations

  • Small sample size

Cite This Study

Moore et al. (2026) studied this question.

synapsesocial.com/papers/6a3f97bb125782b61d865926https://doi.org/10.1093/europace/euag105.929
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