Why the study?
Does nanosecond pulsed field ablation (nsPFA) safely and effectively achieve pulmonary vein and posterior wall isolation in atrial fibrillation patients undergoing concomitant cardiac surgery?
Population
43 patients with atrial fibrillation undergoing concomitant cardiac surgery.
Design
Cohort
Follow-up
6 to 12 months
Key result
Concomitant surgical ablation using the nsPFA clamp was safe with no device-related complications and achieved persistent pulmonary vein isolation in 80% of high-dose patients.
Authors
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Durable PVI rates in this small series support further evaluation; leaves open clinical impact in randomized trials.
Does nanosecond pulsed field ablation (nsPFA) safely and effectively achieve pulmonary vein and posterior wall isolation in atrial fibrillation patients undergoing concomitant cardiac surgery?
This first-in-human feasibility trial demonstrates that nanosecond pulsed field ablation during concomitant cardiac surgery is safe and achieves durable pulmonary vein and posterior wall isolation.
Maesen et al. (2026) studied Atrial fibrillation (n=43). Nanosecond pulsed field ablation (nsPFA) using bipolar surgical ablation clamps was evaluated on Rate of acute major adverse events (MAEs) and events within 30 days postoperatively. Concomitant surgical ablation using the nsPFA clamp was safe with no device-related complications and achieved persistent pulmonary vein isolation in 80% of high-dose patients.
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