Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 27, 2026EP EuropaceOpen Access

Baseline LVEF increased from 50.2 ± 12.7% to 52.7 ± 11.6% (p < 0.001), with ΔLVEF correlating significantly with confirmed/probable capture (ANOVA p < 0.05).

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does the capture type in left bundle branch area pacing affect echocardiographic response and clinical outcomes in paced patients?

Population

655 patients receiving left bundle branch area pacing (LBBAP), median age 75, 67.5% male.

Design

Cohort

Authors

DMD MartinezMPM J PrimoICI Cruz

Discussion

Loading...

Member takes

Overview

Observed LVEF gains in this cohort should not change practice; leaves open need for randomized outcome trials.

Key Points

  • To evaluate the echocardiographic and clinical outcomes after left bundle branch area pacing (LBBAP) and identify predictors of improvement.
  • Prospective analysis of 655 patients receiving LBBAP.
  • Echocardiography assessed left ventricular ejection fraction (LVEF) at baseline and follow-up to calculate ΔLVEF.
  • Logistic regression and Cox proportional hazards models analyzed predictors of echocardiographic responses and clinical outcomes.
  • Baseline LVEF increased from 50.2% to 52.7% (p < 0.001), with 4.1% showing significant improvement.
  • Capture was confirmed in 75.8%, with low clinical event rates: mortality 6.6%, HF hospitalization 1.7%, and composite endpoint 8.4%.
  • Age was an independent predictor of composite events (HR 1.07 per year, p = 0.04), while capture category was not significant after adjustment.

Structured PICO

Does the capture type in left bundle branch area pacing affect echocardiographic response and clinical outcomes in paced patients?

P
Population
655 patients receiving left bundle branch area pacing (LBBAP), median age 75, 67.5% male.
I
Intervention
Left bundle branch area pacing (LBBAP)
O
Outcome
Change in left ventricular ejection fraction (ΔLVEF) and echocardiographic response (ΔLVEF > 10%)surrogate

LBBAP results in modest but consistent improvement in systolic function, with the greatest benefit seen in patients with confirmed or probable capture.

Cite This Study

Martinez et al. (2026) studied this question.

synapsesocial.com/papers/6a3f9785125782b61d8657ebhttps://doi.org/10.1093/europace/euag105.705
View Full Paper
Ask AI
Bookmark
Share