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June 27, 2026EP EuropaceOpen Access

Temperature feedback was significantly affected by tissue type (ΔT=0.95±0.64 °C for scar vs 1.90±0.92 °C for healthy tissue, p<0.0001), and PFA in scar tissue led to a significant increase in sub-endocardial dense scar areas (+13.25% acutely and +6.69% chronically, p<0.01).

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Why the study?

Does unipolar pulsed-field ablation create durable lesions in healthy and scarred ventricular tissue in a sheep model?

Population

Sheep model of post-ischemic ventricular substrate created using two embolization coils

Comparison

Unipolar pulsed-field ablation with a focal… vs Healthy ventricular myocardium vs. post-ischemic…

Design

Preclinical

Follow-up

1 month

Authors

GCG CaluoriKVK VlachosDED El-Hamrani

Discussion

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Overview

Requires caution applying PFA to ventricular scar; animal data leaves open human VT outcomes.

Key Points

  • This research aims to characterize pulsed-field ablation (PFA) lesions in healthy and diseased ventricular tissue to understand their dependence on tissue properties.
  • A sheep model of post-ischemic ventricular substrate was created using embolization coils.
  • Cardiac MRI and unipolar PFA were performed one month later, with histopathological analysis conducted thereafter.
  • Imaging was repeated acutely and at one month to assess lesion characteristics.
  • PFA induced durable low-voltage areas in both scar and healthy ventricular tissue.
  • Temperature feedback varied significantly with tissue type (p<0.0001), affecting ablation depth which plateaued after two applications.
  • Histological analysis revealed differences in collagen distribution between PFA lesions and post-ischemic scars, suggesting distinct maturation processes.

Structured PICO

Does unipolar pulsed-field ablation create durable lesions in healthy and scarred ventricular tissue in a sheep model?

P
Population
Sheep model of post-ischemic ventricular substrate created using two embolization coils
I
Intervention
Unipolar pulsed-field ablation (PFA) with a focal lattice catheter
C
Comparator
Healthy ventricular myocardium vs. post-ischemic scar tissue
O
Outcome
Features of acute and chronic PFA lesions assessed by cardiac MRI and picrosirius red histopathologysurrogate

In a preclinical sheep model, pulsed-field ablation created durable lesions in both healthy and scarred ventricular tissue, with lesion characteristics and temperature feedback significantly dependent on the underlying tissue properties.

Cite This Study

Caluori et al. (2026) studied this question.

synapsesocial.com/papers/6a3f9785125782b61d8657dehttps://doi.org/10.1093/europace/euag105.236
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of pulsed field ablation dose and contact force on atrial lesion transmurality and contiguity: prospective evaluation in a porcine beating heart model2026
  2. 2Multimodal MRI-based assessment of atrial acute and chronic radiofrequency and pulsed field ablation lesions characteristics in a porcine model2026
  3. 3Modified Unipolar Return Pulsed Field Ablation in Ventricular Myocardium2025 · 4 citations
  4. 4Revisiting ventricular tachycardia ablation: insights into pulsed field energy. A systematic review and meta-analysis of prospective studies2026
  5. 5Pulsed-field ablation using a circular multielectrode catheter for persistent atrial fibrillation: procedural outcomes and lesion durability2026