Cross-sectional study evaluates urinary albumin-to-creatinine ratio in PCOS phenotypes, suggesting metabolic burden doesn't equate to microvascular health implications.
Key Points
This study aims to evaluate urinary albumin-to-creatinine ratio across different phenotypes of polycystic ovary syndrome (PCOS) and its relation to metabolic parameters.
Cross-sectional study with 180 women aged 18-35 years with PCOS and 51 healthy controls.
PCOS phenotypes classified per Rotterdam criteria: A (n=96), B (n=19), C (n=35), D (n=30).
Insulin resistance was assessed via HOMA-IR and urinary albumin/creatinine levels were measured.
U-ACR was significantly elevated in Phenotype B compared to controls (p=0.018) and Phenotype D (p=0.016).
Phenotype A had a higher metabolic profile but no U-ACR elevation.
No significant correlation was found between U-ACR and age, BMI, or HOMA-IR.