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June 27, 2026Discover OncologyOpen Access

Exploring shared biomarkers and their mechanisms in thyroid cancer and systemic lupus erythematosus via bioinformatics analysis

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Authors

RLRuijiao LiuXDXiulin DongYLYinan Lu

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Overview

Bioinformatics analysis reveals shared pathways and hub genes linking thyroid cancer and lupus, suggesting novel interventions.

Key Points

  • This study aims to explore shared molecular mechanisms between thyroid cancer and systemic lupus erythematosus using bioinformatics.
  • Acquired gene expression data for thyroid cancer and lupus from GEO database.
  • Identified and analyzed 46 differentially expressed genes (DEGs) shared by both diseases.
  • Assessed immune infiltration and developed protein-protein interaction networks to identify key hub genes.
  • Identified 46 DEGs enriched in immune-inflammatory and complement pathways.
  • Six core hub genes (C1QB, LCN2, C1QC, LTF, VSIG4, C3AR1) showed significant diagnostic potential.
  • Elevated levels of C1QC and C3AR1 predicted improved overall survival in thyroid cancer patients.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6817aea7db3c1953f43bhttps://doi.org/10.1007/s12672-026-05493-0
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