Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 27, 2026Diabetology & Metabolic SyndromeOpen Access

The effect of olanzapine on diabetes related index in humans: a systematic review and meta-analysis of randomized controlled trials

View Full Paper
Ask AI
Bookmark
Share

Authors

RYRidong YouMSMohammad SafargarKPKousalya Prabahar

Discussion

Loading...

Member takes

Overview

Randomized trial evaluates olanzapine's effects on diabetes biomarkers in humans, highlighting metabolic risks.

Key Points

  • The aim is to assess the impact of olanzapine on diabetes-related biomarkers in humans, focusing on its metabolic effects.
  • Conducted a systematic review and meta-analysis of randomized controlled trials (RCTs).
  • Included studies that compared olanzapine with placebo or no treatment, focusing on FBS, fasting insulin, and HbA1c.
  • Performed pooled effect estimates as weighted mean differences using random-effects models.
  • Olanzapine treatment significantly increased fasting blood sugar (WMD: 2.618 mg/dL; 95% CI: 0.283 to 4.954).
  • Fasting insulin levels also rose significantly (WMD: 3.636 µIU/mL; 95% CI: 1.964 to 5.307).
  • No statistically significant change was observed in glycated hemoglobin levels (WMD: −0.029%; 95% CI: −0.284 to 0.226).

Cite This Study

You et al. (2026) studied this question.

synapsesocial.com/papers/6a3f67e2aea7db3c1953f32dhttps://doi.org/10.1186/s13098-026-02223-y
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Impact of Adjunctive Aripiprazole on Olanzapine‐Induced Metabolic Adverse Effects in Patients With Schizophrenia: A Systematic Review2025
  2. 2The effect of olanzapine on lipid profiles in humans: a time and dose response meta-analysis of randomized controlled trials2026
  3. 3Real-World Evidence on Low-Dose Olanzapine (≤1.25 mg) for Personalized Antipsychotic Dosing2025
  4. 4The efficacy of metformin in counteracting olanzapine-induced hyperprolactinemia: an open-label prospective study2025
  5. 5Investigating the effects of olanzapine on appetite and weight in patients with cancer in a systematic review2026