Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 27, 2026Scientific ReportsOpen Access

Plasma CXCL13 and fibrosis biomarkers in COVID-19 compared with idiopathic pulmonary fibrosis

View Full Paper
Ask AI
Bookmark
Share

Authors

NGNicolas GendronCRCarla RialCMClément R. Massonnaud

Discussion

Loading...

Member takes

Overview

Single-center prospective trial examines biomarkers in lung injury for COVID-19 and idiopathic pulmonary fibrosis, indicating their clinical relevance.

Key Points

  • This study aims to evaluate biomarkers associated with lung injury in COVID-19 compared to idiopathic pulmonary fibrosis (IPF).
  • Single-center prospective study involving 154 hospitalized and 10 outpatient COVID-19 patients, 62 IPF patients, and 40 healthy volunteers.
  • Assessment of biomarkers including CXCL13 and Galectin-3 related to alveolar dysfunction and fibrosis.
  • Validation of findings in an independent cohort from the DisCoVeRy trial.
  • COVID-19 patients had higher plasma levels of CXCL13, Galectin-3, and OPN compared to IPF patients at admission.
  • Elevated CXCL13 is associated with increased risk of severe lung injury (odds ratio 3.17, 95% CI 1.03–9.76) and in-hospital mortality (p = 0.04).
  • COVID-19 shows significantly increased extracellular matrix and macrophage activation biomarkers compared to IPF.

Cite This Study

Gendron et al. (2026) studied this question.

synapsesocial.com/papers/6a3f67e2aea7db3c1953f265https://doi.org/10.1038/s41598-026-55451-7
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Correlation of CXCL3 levels, Inflammatory Markers, and COVID-19 Infection with Severity of Asthma in Asthmatic Patients2025
  2. 2Pulmonary fibrosis after COVID-19 is characterized by airway abnormalities and elevated club cell secretory protein-162025
  3. 3Serum fibrinogen levels and lung fibrosis in COVID-19 patients2026
  4. 4Shapley additive explanations based feature selection reveals CXCL14 as a key immune-related gene in predicting idiopathic pulmonary fibrosis2025
  5. 5Identification of blood immunological biomarkers of SARS-CoV-2 infection during pandemic in Poland2025