Case-control study examines correlation of coronary artery calcification with biochemical and inflammatory markers in type 2 diabetes mellitus.
Key Points
The study aims to examine the relationship between coronary artery calcification and biochemical as well as inflammatory markers in individuals with Type 2 diabetes.
Case-control study conducted with 184 individuals with Type 2 diabetes and 184 healthy controls.
Coronary artery calcium score assessed using cardiac non-contrast computed tomography and the Agatston method.
Biochemical and inflammatory markers measured using enzymatic colorimetric methods and immunoassays.
Individuals with Type 2 diabetes exhibited significantly higher coronary artery calcification scores compared to healthy subjects (p < 0.0001).
CACS positively correlated with age, HbA1c, and low-density lipoprotein levels (p < 0.0001, p < 0.0001, p = 0.041 respectively).
Elevated HbA1c and hs-CRP are independent predictors of coronary artery calcification in Type 2 diabetes patients.