Longitudinal cohort study analyzes kidney function trajectories in transgender veterans, suggesting individualized monitoring is necessary.
Key Points
To compare serum creatinine levels and eGFR slopes in transgender individuals receiving hormone therapy versus cisgender controls.
Longitudinal cohort study of veterans from January 2006 to December 2019
Assessment of serum creatinine and eGFR using algorithms based on gender identity and sex assigned at birth
Generalized linear mixed effect models and two-way fixed effects models to evaluate kidney function changes.
Serum creatinine increased in transgender men by three months after hormone therapy initiation with stabilization by twelve months, while transgender women showed no significant changes.
eGFR was significantly lower in transgender men post hormone therapy initiation, whereas it remained stable in transgender women.