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June 19, 2026Minerva Medica

Iron deficiency and risk of acute kidney injury after TAVI: a machine learning analysis

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Key result

Iron deficiency emerges as the top predictor of post-TAVI AKI.

  • n=116

Why the study?

Does iron deficiency predict acute kidney injury within 48 hours after TAVI in patients with severe aortic stenosis?

Population

116 consecutive patients with severe aortic stenosis who underwent TAVI, mean age 76±6.5 years, 57% male.

Design

Cohort

Follow-up

48 hours (for primary endpoint)

Authors

ACAngelica CersosimoCRCrina-Ioana RadulescuMAMarianna ADAMO

Discussion

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Overview

Ferritin and TSAT may aid post-TAVI AKI risk stratification; hypothesis-generating until validated prospectively.

Key Points

  • The aim is to identify independent predictors of acute kidney injury (AKI) after transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis.
  • Retrospective, observational study of consecutive patients undergoing TAVI from December 2022 to December 2023.
  • Used eXtreme Gradient Boosting (XGBoost) algorithm for predictive modeling, with SHAP for interpretability.
  • Included 116 patients with baseline characteristics and evaluated post-procedural AKI rates.
  • AKI occurred in 9% of patients within 48 hours post-TAVI.
  • Ferritin and TSAT were identified as the most influential predictors of AKI (p-values not specified).
  • The machine learning model showed 96% sensitivity and an F1-score of 0.98, indicating strong predictive capability.

Study Design

Type

Observational (n=116)

Multicenter

No

Structured PICO

Does iron deficiency predict acute kidney injury within 48 hours after TAVI in patients with severe aortic stenosis?

P
Population
116 patients (mean age 76 years, 43% female) with severe aortic stenosis undergoing TAVI, evaluated for predictors of acute kidney injury within 48 hours.
E
Exposure
Transcatheter aortic valve implantation (TAVI)
O
Outcome
Independent predictors of acute kidney injury (AKI) within 48 hours after TAVIsafety

Iron deficiency, indicated by low ferritin and TSAT levels, is a strong independent predictor of early acute kidney injury following TAVI, suggesting utility for early risk stratification.

Cite This Study

Cersosimo et al. (2026) conducted an observational in severe aortic stenosis (n=116). Iron deficiency was evaluated on Independent predictors of acute kidney injury (AKI) within 48 hours after TAVI. In patients undergoing TAVI, iron deficiency emerged as the top predictor of acute kidney injury (9% overall incidence) in a machine learning model with 96% sensitivity and an F1-score of 0.98.

synapsesocial.com/papers/6a359850dd3be7785e70ed8ahttps://doi.org/10.23736/s0026-4806.26.09884-8
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